W.M. Keck Foundation Career Development Professor; Assistant Professor
Trinity College DublinMsc
National University of Ireland, GalwayBE
Research in the Therapeutic Technology Design and Development Lab incorporates soft robotics, unique fabrication methods and computational analysis tools into the device design process to develop novel therapeutic strategies for tissue repair. We design and develop implantable medical devices that augment or assist native function. We borrow principles from nature to design implantable, biomimetic therapeutic devices. Research is broadly categorized into three areas (i) mechanical assist and repair devices, (ii) biomaterial and therapy delivery devices and (iii) enhanced preclinical test model development. Ultimately, the combined aim of our work is to translate enhanced therapeutic devices into the clinical arena. Our lab has strong collaborations with surgeons and interventionalists from local hospitals for constant input into the device design process and to enable accurate development of clinically representative laboratory and pre-clinical test protocols.
American Heart Association
Americal Society of Mechanical Engineers
National Academy of Advancement in Science
Biomedical Engineering Society
Frontiers of Engineering
Reviewer, National Science Foundation
Ad Hoc Reviewer: Nature Medicine, Science Robotics, Soft Robotics, Annals of Biomedical Engineering,
Publication Chair, BioRob 2020
Medical Engineering and Medical Physics Admissions Committee
Health Sciences and Technology Medical Engineering and Medical Physics Academic Advisor
Health Sciences and Technology Integrated Committee for Academic Programs Committee
Fall 2017 - 2.75 Medical Device Design
Fall 2018, Fall 2019- 2.009 Product Design
Spring 2019,2020 - HST.100 Respiratory Pathophysiology
Roche ET. Not “dust” any neural stimulator. Science Translational Medicine 18 Mar 2020:Vol. 12, Issue 535, eabb2775. DOI: 10.1126/scitranslmed.abb2775.
Park C, Fan Y, Hager G, Yuk H, Singh M, Rojas A, Hameed A, Saeed M, Vasilyev NV, Steel TJW, Zhao X, Nguyen CT*, Roche ET*. An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging. Science Robotics 5;38;eaay9106. DOI: 10.1126/scirobotics.aay9106.
Yuk, H., Varela, C.E., Nabzdyk, C.S. et al. Dry double-sided tape for adhesion of wet tissues and devices. Nature 575, 169–174 (2019). https://doi.org/10.1038/s41586-019-1710-5
Dolan EB, Varela CE, Mendez K, Whyte W, Levey RE, Robinson ST, Maye E, O’Dwyer J, Beatty A, Rothman A, Fan Y, Hochstein J, Rothenbucher S, Wylie R, Starr JR, Monaghan M, Dockery P, Duffy GP, Roche ET. An actuatable soft reservoir modulates host foreign body response. Science Robotics 4;33;eaax7043 https://doi.org/10.1126/scirobotics.aax7043
Cobi A, Gray L , Mittmann E, Link S, Hanumara N, Lyatskaya Y, Roche, ET, Slocum A , Zygmanski P (2019). Design of a Reconfigurable Quality Assurance Phantom for Verifying the Spatial Accuracy of Radiosurgery Treatments for Multiple Brain Metastases. Journal of Medical Devices. 13. 10.1115/1.4044402.
Shirazi RN, Islam S, Weafer FM, Villanyi A, Ronan W, McHugh PE, Roche ET. Multi-scale experimental and computational modeling approaches to characterize therapy delivery to the heart from an implantable epicardial biomaterial reservoir. Advanced Healthcare Materials 8 (16), 1970068 https://doi.org/10.1002/adhm.201900228
Fan Y, Ronan W, Teh I, Schneider JE, Varela CE, Whyte W, McHugh PE, Leen SB, Roche ET. A comparison of two quasi‐static computational models for assessment of intra‐myocardial injection as a therapeutic strategy for heart failure, International Journal of Numerical Methods in Biomedical Engineering, 25:9:e2313, 2019 https://doi.org/10.1002/cnm.3213
Roche, ET, Implanted Device Enables Responsive Bladder Control. Nature News and Views, January 2nd, 2019. doi: 10.1038/d41586-018-07811-1
Varela C, Fan Y and Roche ET, Optimizing epicardial restraint and reinforcement following myocardial infarction: Moving towards localized, biomimetic, and multitherapeutic options (2019). Biomimetics, 4;1;7
Weafer FM, Duffy S, Machado IP, Roche ET, McHugh PE, Gilvarry M. Characterization of Strut Indentation during Mechanical Thrombectomy in Acute Ischemic Stroke Clot Analogues (2019). Journal of NeuroInterventional Surgery,11;9;891-897
Whyte W*, Roche ET*, Shahrin I, Shirazi RS, Weafer, F, Mendez K, O’Neill HS, Vasilyev NV, McHugh PM, Murphy B, Duffy GP**, Walsh CJ**, and Mooney DJ**, Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir (2019). Nature Biomedical Engineering 2:6:416 https://doi.org/10.1038/s41551-018-0247-5 *co first-authors ** co senior authors
Horvath MA, Varela CE, Dolan EB, Whyte W, Monahan DS, Payne CJ, Wamala IA, Vasilyev NV, Pigula FA, Mooney DJ, Walsh CJ, Duffy GP, Roche ET. Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart. Ann Biomed Eng (2018) 46;10;1534-1547https://doi.org/10.1007/s10439-018-2046-2
Wamala I, Roche ET, Pigula FA, The use of soft robotics in cardiovascular therapy, Expert Review of Cardiovascular Therapy, 15;10, 2017
Horvath MA, Wamala I, Rytkin E, Doyle E, Payne CJ, Thalhofer T, Berra I, Wamala I, Solovyeva A, Saeed M, Hendren S, Roche ET, Del Nido PJ, Walsh CJ, Vasilyev NV. An Intracardiac Soft Robotic Device for Augmentation of Blood Ejection from the Failing Right Ventricle, Annals of Biomedical Engineering, 1-12, 2017.
Payne CJ. Wamala I, Abah C, Thalhofer T, Saeed M, Bautista-Salinas D, Horvath MA, Vasilyev NV, Roche ET, Pigula FA, Walsh CJ. Soft robotic ventricular assist device with septal bracing for therapy of heart failure. Soft Robotics 4;3;241-250.
Roche ET, Horvath MA, Wamala I, Alazmani A, Song SE, Whyte W, Machaidze Z, Vasilyev NV, Mooney DJ, Pigula FA, and Walsh CJ. Soft Robotic Sleeve Restores Heart Function. Science Translational Medicine, 9 (373), eaaf3925.
O’Neill HS, Gallagher LB, O’Sullivan J, Whyte W, Curley C, Dolan E, Hameed A, O’Dwyer J, Payne C, O’Reilly D, Ruiz-Hernandez E, Roche ET, F. J. O’Brien, S. A. Cryan, H. Kelly, B. Murphy, and G. P. Duffy. Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives. Advanced Materials 28 (27), 5648-5661.
Cezar CA, Roche ET, Vandenburgh HH, G. N. Duda, Walsh CJ, and Mooney DJ. Biologic-free mechanically induced muscle regeneration. PNAS 113 (6), 1534-1539 DOI10.1073/pnas.1517517113.
Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Casar Berazaluce AM, Cearbhaill ED, Vasilyev NV, Mooney DJ, Karp JM, del Nido, PJ, Walsh CJ. A light reflecting balloon for atraumatic tissue defect closure. Science Translational Medicine (Front cover) 2015: 7(306):149, DOI: 10.1126/scitranslmed.aaa2406
Hastings CL, Roche ET, Ruiz-Hernandez E, Schenke-Layland K, Walsh CJ, Duffy GP. Drug and cell delivery for cardiac regeneration. Advanced Drug Delivery Reviews 2014 DOI:10.1016/j.addr.2014.08.006
Roche ET, Hastings CL, Lewin SA, Shvartsman DE, Brudno Y, Vasilyev NV, O’Brien FJ, Walsh CJ, Duffy GP, Mooney DJ. Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart. Biomaterials 2014. 35(25):6850-8. DOI 0.1016/j.biomaterials.2014.04.114.
Roche ET, Wohlfarth R, Overvelde JTB, Vasilyev NV, Pigula FA, Mooney DJ, Bertoldi K, Walsh CJ. A Bioinspired Soft Actuated Material. Advanced Materials (Front Cover) 2014. 26,1200-1206. DOI: 10.1002/adma.201304018.
Isakov A, Murdaugh K, Burke WC, Zimmerman S, Roche ET, Holland D, Einarsson JI, Walsh CJ. A New Laparoscopic Morcellation Using an Actuated Wire Mesh and Bag. Journal of medical devices 2014:8:011009-5.
Frech AJ, Orozco D, Davoudi K, Ding C, Field R, Yasin R, Roche ET, Holland D and Walsh CJ. Laparoscopic Device for Direct and Indirect Suction. J. Med. Devices 2013:7(3),P030920
Wan Q, Schoppe O, Gunasekaran S, Holland D, Roche ET, Hur H-C, Walsh CJ. Multifunctional laparoscopic trocar with built-in fascial closure and stabilisation. J. Med. Devices 7(3), 030912 (Jul 03, 2013)
O’Flynn P, Roche ET, Pandit A. Generating an ex vivo vascular model. ASAIO 2005; 51(4):426-33
US Patent 7591198 (grant) Apparatus and System for measuring of particles generated from medical devices or instruments utilized during simulated clinical applications, Issued September 22nd 2009
US Patent 7591199 (grant) Method for measuring of particles generated from medical devices or instruments utilized during simulated clinical applications, Issued September 22nd 2009
US Patent Application 2008073817 Forming Pre- Made pieces of PVA into specific models,Issued March 27, 2008
US Patent Application 2008076101 Forming Vascular Diseases within Anatomical Models,Issued March 27, 2008
US Patent Application 2008073022 Multi-Piece PVA models with non-brittle connections,Issued Mar 27, 2008
US Patent Application 2007110280 Methods for Determining Coating Thickness of a Prosthesis, Issued May 17, 2007