Roger D. KammProfessor of Biological and Mechanical Engineering
Cecil and Ida Green Distinguished Professor
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge MA 02139-4307
Room NE 47-322
Ph.D. in Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, May, 1977
S.M. in Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, August 1973
B.S. in Mechanical Engineering, Northwestern University, Evanston, IL, June 1972
2011-present: Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering
2010-2011: Singapore Research Professor of Biological and Mechanical Engineering
2005-2010: Germeshausen Professor of Mechanical and Biological Engineering
2005-2008: Associate chair of Mechanical Engineering
1998-present: Professor of Bioengineering, M.I.T.
1988-present: Professor of Mechanical Engineering, M.I.T.
1988-2014: Professor of Health Sciences and Technology, M.I.T. and Harvard University
1981-1988: Associate Professor of Mechanical Engineering, M.I.T.
1978-1981: Assistant Professor of Mechanical Engineering, M.I.T.
1977-1978: Lecturer and Research Associate in the Department of Mech. Engineering, M.I.T.
1977: Instructor, M.I.T.
Other Related Experience:
2010-present: Director, NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems
1994-present: Associate Director, Center for Biomedical Engineering, M.I.T.
1992-1994: Co-Director: Program in Biomedical Engineering, M.I.T.
1986-1987: Senior Visiting Scientist, University of Cambridge, Department of Applied Mathematics and Theoretical Physics. Visiting Fellow, Clare Hall, University of Cambridge.
United States Patent 4,446,747 Kamm May 8, 1984
Method and apparatus for testing lip pressure applied to a smoking article and for calibrating the pressure testing apparatus
United States Patent 5,954,745 Gertler and Kamm, September 21, 1999
Catheter-filter set having a compliant seal
(patent rights to Embolic Protection, Inc., subsequently purchased by Boston Scientific)
United States Patent 6,117,087 Kamm, et al. September 12, 2000
Method and apparatus for noninvasive assessment of a subject's cardiovascular system
United States Patent 6,605,053 Kamm, et al. August 12, 2003
Conduit designs and related methods for optimal flow control
PCT/US 20110159522 Application, Kamm et al., Filed April, 2008
Three-dimensional microfluidic platforms and methods of use thereof
Provisional patent application, Borenstein et al., October 6, 2009.
Improvements to three-dimensional microfluidic platforms and methods of use thereof
PCT/US11/54029, Kamm et al., Filed October 19, 2010
Device for High Throughput Investigations of Multi-Cellular Interactions
United States Patent Application No. 13/743,223, Ragunath et. al., Filed January 16, 2013
Compositions and Methods for Neovasuclarization
2000 Cardiovascular Technologies (with Dr. Jonathan Gertler) Developing vascular filtration systems for carotid angioplasty. Technology ultimately purchased by Boston Scientific.
2012 AIM Biotech (with Dr. Seok Chung) Developing microfluidic systems for heterotypic, 3D cell culture and drug screening for metastatic cancers.
Publications (Last two years):
Aref AR, Huang RY-J, Yu W, Chua K-N, Sun W, Tu T-Y, Sim W-J, Zervantonakis IK, Thiery JP, Kamm RD. Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb). 2013 Feb;5(2):381-9. doi: 10.1039/c2ib20209c PMID: 23172153 [PubMed - indexed for MEDLINE]
Rimchala T, Kamm RD, Lauffenburger DA. Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines. Integr Biol (Camb). 2013 Jan 10. [Epub ahead of print] PMID: 23303249
Jeon JS, Zervantonakis IK, Chung S, Kamm RD, Charest JL. In vitro model of tumor cell extravasation. PLoS One. 2013;8(2):e56910. doi: 10.1371/journal.pone.0056910. Epub 2013 Feb 20. PMID: 23437268
Hammond NA, Kamm RD. Mechanical characterization of self-assembling peptide hydrogels by microindentation. J Biomed Mater Res B Appl Biomater. 2013 Mar 26. doi: 10.1002/jbm.b.32906. PMID: 23529940
Liu F, Wu D, Kamm RD, Chen K. Analysis of nanoprobe penetration through a lipid bilayer. Biochim Biophys Acta. 2013 Mar 20. doi:pii: S0005-2736(13)00074-6. 10.1016/j.bbamem.2013.03.011. PMID: 23524226
Kim MC, Neal DM, Kamm RD, Asada HH. Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol. 2013 Feb;9(2):e1002926. doi: 10.1371/journal.pcbi.1002926. Epub 2013 Feb 28.
Hammond NA, Kamm RD. Mechanical characterization of self-assembling peptide hydrogels by microindentation. J Biomed Mater Res B Appl Biomater. 2013 Aug;101(6):981-90. doi: 10.1002/jbm.b.32906. Epub 2013 Mar 26. PMID: 23529940
Kothapalli CR, Kamm RD. 3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages. Biomaterials. 2013 Aug;34(25):5995-6007. doi: 10.1016/j.biomaterials.2013.04.042. Epub 2013 May 18. PMID: 23694902
Polacheck WJ, Li R, Uzel SG, Kamm RD. Microfluidic platforms for mechanobiology. Lab Chip. 2013 Jun 21;13(12):2252-67. doi: 10.1039/c3lc41393d. Epub 2013 May 7. PMID: 23649165
Hesse WR, Steiner M, Wohlever ML, Kamm RD, Hwang W, Lang MJ. Modular aspects of kinesin force generation machinery. Biophys J. 2013 May 7;104(9):1969-78. doi: 10.1016/j.bpj.2013.03.051.
Borau C, Kamm RD, García-Aznar JM. A time-dependent phenomenological model for cell mechano-sensing. Biomech Model Mechanobiol. 2013 Jun 20. [Epub ahead of print]
Kamm RD, Bashir R. Creating Living Cellular Machines. Ann Biomed Eng. 2013 Sep 5. [Epub ahead of print] PMID: 24006130
Chen MB, Whisler JA, Jeon JS, Kamm RD. Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. Integr Biol (Camb). 2013 Sep 23; 5(10):1262-71. doi: 10.1039/c3ib40149a. PMID: 23995847
Rahim NAA, Pelet S, Mofrad MRK, So PTC, Kamm RD, Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy, Methods (2013), doi: http://dx.doi.org/10.1016/j.ymeth.2013.10.007
Kim MC, Neal DM, Kamm RD, Asada HH, Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol. 2013;9(2):e1002926. doi: 10.1371/journal.pcbi.1002926. Epub 2013 Feb 28.
Lim SH, Kim C, Aref AR, Kamm RD, Raghunath M, Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting, Integr Biol (Camb), 2013, DOI: 10.1039/c3ib40082d.
Tu TY, Wang Z, Bai J, Sun W, Peng WK, Huang RY, Thiery JP, Kamm RD Rapid Prototyping of Concave Microwells for the Formation of 3D Multicellular Cancer Aggregates for Drug Screening. Adv Healthcare Mater. 2013 Aug 27. doi: 10.1002/adhm.201300151. PMID: 23983140
Whisler JA, Chen MB, Kamm RD. Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System. Tissue Eng Part C Methods. 2014 Jul;20(7):543-52. doi: 10.1089/ten.TEC.2013.0370. Epub 2013 Dec 13. PMID: 24151838
Abdul Rahim NA, Pelet S, Mofrad MRK, So PTC, Kamm RD, Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy, Methods. 2014 Mar 15;66(2):208-21. doi: 10.1016/j.ymeth.2013.10.007. Epub 2013 Oct 31. PMID: 24184188
Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA, Vascular Endothelial Growth Factor and Platelet Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context. Mol Cell Proteomics. 2013 Dec;12(12):3704-18. doi: 10.1074/mcp.M113.030528. Epub 2013 Sep 9. PMID: 24023389
Bersini S, Jeon JS, Moretti M, Kamm RD. In vitro models of the metastatic cascade: from local invasion to extravasation. Drug Discov Today. 2013 Dec 17. pii: S1359-6446(13)00424-8. doi: 10.1016/j.drudis.2013.12.006. [Epub ahead of print] PMID: 24361339
Ochs CJ, Kasuya J, Pavesi A and Kamm RD, Oxygen levels in thermoplastic microfluidic devices during cell culture, Lab Chip, 2014, 14 (3), 459 - 462, DOI:10.1039/C3LC51160J
Bersini S, Jeon JS, Dubini G, Arrigoni C, Charest JL, Moretti M, Kamm RD, A mircrofluidic 3D in vitro model for specificity of breast cancer metastasis to bone, Biomaterials. 2014 Mar;35(8):2454-61. doi: 10.1016/j.biomaterials.2013.11.050. Epub 2013 Dec 31. PMID: 24388382
Park YK, Tu TY, Lim SH, Clement IJM, Yang SY, Roger D. Kamm RD, In Vitro Microvessel Growth and Remodeling within a Three-dimensional Microfluidic Environment, Cell Mol Bioeng. 2014 Mar 1;7(1):15-25. PMID: 24660039 [PubMed]
Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD. Mechanotransduction of fluid stresses governs 3D rheotaxis, Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2447-52. doi: 10.1073/pnas.1316848111. Epub 2014 Feb 3. PMID: 24550267
Tang D, Kamm RD, Yang C, Zheng J, Canton G, Bach R, Huang X, Hatsukami TS, Zhu J, Ma G, Maehara A, Mintz GS, Yuan C. Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: Data, modeling, validation, uncertainty and predictions. J Biomech. 2014 Mar 3;47(4):834-46. doi: 10.1016/j.jbiomech.2014.01.012. Epub 2014 Jan 14. PMID: 24480706 [PubMed - in process]
Niu Y, Bai J, Kamm RD, Wang Y, Wang C. Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment. Mol Pharm. 2014 Jul 7;11(7):2022-9. doi: 10.1021/mp500054h. Epub 2014 Feb 24. PMID: 24533867 [PubMed - in process]
Jeon JS, Bersini S, Whisler JA, Chen MB, Dubini G, Charest JL, Moretti M, Kamm RD. Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb). 2014 May;6(5):555-63. doi: 10.1039/c3ib40267c. PMID: 24676392
Bao G, Bazilevs Y, Chung JH, Decuzzi P, Espinosa HD, Ferrari M, Gao H, Hossain SS, Hughes TJ, Kamm RD, Liu WK, Marsden A, Schrefler B. USNCTAM perspectives on mechanics in medicine. J R Soc Interface. 2014 Aug 6;11(97):20140301. doi: 10.1098/rsif.2014.0301. PMID: 24872502 [PubMed - in process]
Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL. Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells. Stem Cell Rev. 2014 Sep 5. [Epub ahead of print] PMID: 25190668
Uzel SG, Pavesi A, Kamm RD. Microfabrication and microfluidics for muscle tissue models. Prog Biophys Mol Biol. 2014 Aug 28. pii: S0079-6107(14)00088-1. doi: 10.1016/j.pbiomolbio.2014.08.013. [Epub ahead of print] PMID: 25175338
Borau C, Polacheck WJ, Kamm RD, Garcia-Aznar JM. Probabilistic voxel-fe model for single cell motility in 3D. In Silico Cell and Tissue Science, 1:2, 2014.
Mak M, Kamm RD, Zaman MH. Impact of Dimensionality and Network Disruption on Microrheology of Cancer Cells in 3D Environments. PLoS Comput Biol. 2014 Nov 20;10(11):e1003959. doi: 10.1371/journal.pcbi.1003959. eCollection 2014 Nov, PMID: 25412385
Kim C, Kasuya J, Jeon J, Chung S, Kamm. A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs. Lab Chip. 2014 Dec 3;15(1):301-10. doi: 10.1039/c4lc00866a. PMID: 25370780
Jeon, Jessie S; Bersini, Simone; Gilardi, Mara; Dubini, Gabriele; Charest, Joseph L; Moretti, Matteo; Kamm, Roger D; Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation, Proceedings of the National Academy of Sciences, pp. 201417115, 2014
Borau, Carlos; Kamm, Roger D; Garcia-Aznar, Jose Manuel; A time-dependent phenomenological model for cell mechano-sensing, Biomechanics and modeling in mechanobiology. 13(2): 451-462, 2014
Scientific & Professional Societies:
American Institute for Medical and Biological Engineering (Fellow)
American Society of Mechanical Engineering (Fellow)
Biomedical Engineering Society (Fellow)
Honors & Awards: (last five years).
Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching (2001)
Cambridge/MIT Fellow (2001)
Eschbach Distinguished Visiting Scholar Award, Northwestern University (2002)
Fellow, American Society of Mechanical Engineering (2003)
Distinguished Lecturer in Biomechanics, Stanford University, (2004)
Fellow, Biomedical Engineering Society (2004)
Fellow, International Academy of Medical and Biological Engineering (2005)
Skalak Memorial Lecture, UC San Diego, (2007)
Midwest Mechanics Lecturer (2007-8)
Lissner Medal (for lifetime achievement), ASME Bioengineering Division (2010)
Fellow, American Academy for the Advancement of Science (2010)
Elected to the Institute of Medicine (2010)
Honorary Member, American Venous Forum (2011)
Huiskes Medal, European Society of Biomechanics (2015)
Institutional and Professional Service (last five years):
Biomedical Engineering Society; Chair, Awards Committee (1989-91)
Board of Directors (1994-1997) (2003-2007)
Publications Board, Member (2000-2006)
ASME Journal of Biomechanical Engrg., Associate Editor (1990-1996)
NHLBI, NIEHS, NASA, NSF; Review Committees (1988-present)
Journal of Fluids and Structures, Associate Editor (1993-2005)
US National Committee on Biomechanics; (1997-present)
Vice chair (2003-2006)
World Council on Biomechanics (1998-present);
Vice chair (2002-2006)
External Review Board, City University of New York, Biomedical Engineering Doctoral Program (1999)
External Advisory Board, Northwestern University, Dept. of Biomedical Engineering (2000-2006)
Summer Bioengineering Conference, Conference Chair, 2001
Biomechanics and Modeling in Mechanobiology, Editorial Board, (2001-present)
External Review Board, Pennsylvania State University, Dept. of Biomedical Engineering (2003)
External Review Board, Duke University, Dept. of Biomedical Engineering (2003)
1st Annual Symposium on Frontiers in Biomechanics, Co-organizer, (2003)
Mechanics & Chemistry of Biosystems, Editorial Board (2003-present)
Hypertension & Microcirculation Study Section, NIH (2004-2008)
Expert Panel, Strategy for the EuroPhysiome (STEP) project (2006-2007)
External Advisory Board, Simbios Center, Stanford University (2006- 2010)
Co-organizer, Summer Course on Molecular and Cell Biomechanics, MIT (2006)
Co-organizer, Summit of Experts in Biomechanics, Keystone, CO (2007)
Advisory Board, Indian Institute of Technology, Kampur, (2007- 2008)
External Review Committee, UC Berkeley Bioengineering Dept., (2007)
Scientific Advisory Board, VPH Network of Excellence (2007- 2010)
Director, Global Enterprise for MicroMechanics and Molecular Medicine (GEM4) (2007-2010)
Co-organizer, The Cell as a Machine Workshop, Arlington, VA (2007)
External Advisory Committee, Chilean Nanotechnology Initiative (2008)
Organizing Committee, 5th International Biofluids Symposium (2007)
Community Giving at MIT Campaign Committee (Chair, 2007-2009)
Scientific Advisory Board, CIBER BBN, Spain (2008-2013)
Scientific Advisory Board, Global Center of Excellence in Nano-Bioengineering, Sendai, Japan (2006-2012)
Chair, International Academy of Medical and Biological Engineering (2011-2014)
Current Editorial Boards: Journal of Multiscale Modeling, Cellular and Molecular Bioengineering, Methods in Cell Science, Cellular and Molecular Bioengineering, Biomedical Engineering Letters, Journal Royal Society Interface
Current Advisory Boards: Imperial College, EPSRC Centre for Doctoral Training in Fluid Dynamics across Scales; Biomedical Engineering Department at the University of Texas, Austin; Institute of Biological Engineering in Catalonia; Department of BioMedical Engineering, Technische Universiteit at Eindhoven, Netherlands.