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Roger Kamm

Contact Info

room NE47-321

Massachusetts Institute of Technology

77 Massachusetts Avenue

Cambridge, Massachusetts 02139

Education

  • 1972

    NORTHWESTERN UNIVERSITY

    B.Sc.
  • 1973

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)

    M.Sc.
  • 1977

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)

    Ph.D.

Research Interests

  • Microfluidics
  • Cell mechanics
  • Biological systems
  • Mechanotransduction
  • Tissue engineering
  • Metastatic cancer
  • Microvascular models

Honors + Awards

  • 2018    The Nerem Medal (ASME) for excellence in education and mentoring
  • 2015    The Huiskes Medal (European Biomechanics Society) for lifetime of contributions
  • 2011    Honorary Member (American Venous Forum)
  • 2010    Fellow, AAAS
  • 2010    The Lissner Medal (ASME) for career contributions in bioengineering
  • 2010    Elected to the Institute of Medicine of the National Academies
  • 2005    Fellow, International Academy of Medical and Biological Engineering
  • 2004    Fellow, American Society of Mechanical Engineers
  • 2004    Fellow, Biomedical Engineering Society
  • 2002    Eschbach Distinguished Visiting Scholar Award, Northwestern University
  • 2001    Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching

Memberships

  • American Society of Mechanical Engineers
  • Biomedical Engineering Society
  • America Association for the Advancement of Science
  • American Institute of Medical and Biological Engineering
  • European Biomechanics Society
  • International Academy of Medical and Biological Engineering
  • American Venous Forum
  • National Academy of Medicine

Professional Service

  • Editorial Boards: Journal of Multiscale Modeling, Cellular and Molecular Bioengineering, Methods in Cell Science, Cellular and Molecular Bioengineering, Biomedical Engineering Letters, Journal Royal Society Interface
  • 2014      Chair, World Congress of Biomechanics
  • 2011 – 2015    Chair, International Academy of Medical & Biological Engineers
  • 2007 – 2010    Director, Global Enterprise for MicroMechanics and Molecular Medicine
  • 2004 – 2009    Hypertension and Microcirculation Study Section (regular member)
  • 2003 – 2008    BMES Publications Board (Chair, 2004 – 2006), Board of Directors (2005 – 2008)
  • 2001    Chair, Summer Bioengineering Conference, Snowbird Utah
  • 1998 – 2018    World Council on Biomechanics (Vice Chair, 2002-2006, Chair, 2006-2010)
  • 1997 – 2009    US National Committee on Biomechanics (Secretary-treasurer, 2000 – 03, Vice Chair, 2003 – 2006, Chair, 2006-2009)

Teaching

  • Molecular, Cellular and Tissue Biomechanics (20.310, 20.410, 2.797, 2.798)
  • Fields, Forces and Flows in Biological Systems (20.430, 2.795)

Publications

Publications in the past 3 years:

  1. Uzel SG, Amadi OC, Pearl TM, Lee RT, So PT, Kamm RD. Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform. Small. 2016 Feb;12(5):688. doi: 10.1002/smll.201670025.
  2. M Mak, MH Zaman, RD Kamm, T Kim. Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks Nature Communications, 2016, 7, 10.1038/ncomms10323
  3. Spill F, Reynolds DS, Kamm RD, Zaman MH. Impact of the physical microenvironment on tumor progression and metastasis. Curr Opin Biotechnol. 2016 Feb 29;40:41-48. doi: 10.1016/j.copbio.2016.02.007. [Epub ahead of print] Review. PMID: 26938687 [PubMed - as supplied by publisher]
  4. Boussommier-Calleja, A., Li, R., Chen, M. B., Wong, S. C., & Kamm, R. D. (2016). Microfluidics: A new tool for modeling cancer-immune interactions. Trends in Cancer2(1), 6–19. http://doi.org/10.1016/j.trecan.2015.12.003
  5. Chen MB, Lamar JM, Li R, Hynes RO, Kamm RD. Elucidation of the roles of tumor integrin ß1 in the extravasation stage of the metastasis cascade. Cancer Res. 2016 Mar 17. pii: canres.1325.2015. [Epub ahead of print] PMID: 26988988 [PubMed - as supplied by publisher]
  6. Raman R, Cvetkovic C, Uzel SG, Platt RJ, Sengupta P, Kamm RD, Bashir R. Optogenetic skeletal muscle-powered adaptive biological machines. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3497-3502. Epub 2016 Mar 14.PMID: 26976577 [PubMed - as supplied by publisher]
  7. Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK, Iannello A, Iwamoto Y, Cortez-Retamozo V, Kamm RD, Pittet MJ, Raulet DH, Weinberg RA. Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells. Cancer Discov. 2016 Apr 12. pii: CD-15-1157. [Epub ahead of print] PMID: 27072748 
  8. Adriani G, Pavesi A, Tan AT, Bertoletti A, Thiery J-P, Kamm RD. Microfluidic models for adoptive cell-mediated cancer immunotherapies. Drug Discovery Today.  Available online: 13 May, 2016, DOI: 10.1016/j.drudis.2016.05.006
  9. Adriani G, Bai J, Wong S-C, Kamm RD, Thiery J-P, M2a macrophages induce contact-dependent dispersion of carcinoma cell aggregates, Macrophage, 2016, DOI: 10.14800/Macrophage.1222
  10. Pavesi A, Adriani G, Tay A, Warkiani ME, Yeap WH, Wong SC, Kamm RD. TI Engineering a 3D microfluidic culture platform for tumor-treating field application. Scientific Reports, 2045-2322, MAY 24, 2016, 6, DI 10.1038/srep26584
  11. Uzel SG, Platt RJ, Subramanian V, Pearl TM, Rowlands CJ, Chan V, Boyer LA, So PT, Kamm RD. Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units.Sci Adv. 2016 Aug 3;2(8):e1501429. doi: 10.1126/sciadv.1501429. PMID: 27493991 
  12. Truong D, Puleo J, Llave A, Mouneimne G, Kamm RD, Nikkhah M. Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment.Sci Rep. 2016 Sep 28;6:34094. doi: 10.1038/srep34094. PMID:  27678304 
  13. Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee B, Lee T, Mak SY, Ho YS, Lam KP, Ong CK, Huang RY, Ginhoux F, Rotzschke O, Kamm RD, Wong SC. Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.Oncoimmunology. 2016 Jun 21;5(8):e1191731. doi: 10.1080/2162402X.2016.1191731. PMID: 27622062
  14. Spill F, Andasari V, Mak M, Kamm RD, Zaman MH. Effects of 3D geometries on cellular gradient sensing and polarization.Phys Biol. 2016 Jun 25;13(3):036008. doi: 10.1088/1478-3975/13/3/036008. PMID: 27345945
  15. Takeishi N, Imai Y, Ishida S, Omori T, Kamm RD, Ishikawa T. Cell adhesion during bullet motion in capillaries.Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H395-403. doi: 10.1152/ajpheart.00241.2016.
  16. Cao X, Moeendarbary E, Isermann P, Davidson PM, Wang X, Chen MB, Burkart AK, Lammerding J, Kamm RD, Shenoy VB. A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.Biophys J. 2016 Oct 4;111(7):1541-1552. doi: 10.1016/j.bpj.2016.08.011. PMID: 27705776
  17. Adriani, G., Ma, D., Pavesi, A., Kamm, R. D., & Goh, E. L. K. (2017). A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier. Lab on a Chip.
  18. Li R, Hebert JD, Lee TA, Xing H, Boussommier-Calleja A, Hynes RO, Lauffenburger DA, Kamm RD. Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways.Cancer Res. 2017 Jan 15;77(2):279-290. doi: 10.1158/0008-5472.CAN-16-0442.
  19. TC Bidone, W Jung, D Maruri, C Borau, RD Kamm, T Kim, Morphological Transformation and Force Generation of Active Cytoskeletal Networks, PLoS computational biology 13 (1), e1005277, 2017
  20. YT Ho, G Adriani, S Beyer, PT Nhan, RD Kamm, J Chen, Y Kah, A facile method to probe the vascular permeability of nanoparticles in nanomedicine applications, Scientific Reports (Nature Publisher Group) 7, 1, 2017
  21. N Arora, JI Alsous, JW Guggenheim, M Mak, J Munera, JM Wells, ... A process engineering approach to increase organoid yield, Development 144 (6), 1128-1136, 2017
  22. GS Ugolini, A Pavesi, M Rasponi, GB Fiore, R Kamm, M Soncini, Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro, eLife 6, e22847, 2017
  23. K Haase, RD Kamm, Advances in on-chip vascularization, Regenerative Medicine, 2017
  24. Chen MB, Whisler JA, Fröese J, Yu C, Shin Y, Boussomier A, Kamm RD. On-chip human microvasculature assay for real-time visualization and quantitation of tumor cell extravasation dynamics. Nat Protocols, 12 (5), 865-880, 2017.
  25. Alvarez MM, Aizenberg J, Analoui M, Andrews AM, Bisker G, Boyden ES, Kamm RD, Karp JM, Mooney DJ, Oklu R, Peer D, Stolzoff M, Strano MS, Trujillo-de Santiago G, Webster TJ, Weiss PS, Khademhosseini A.. Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation. ACS Nano. 2017 May 19. doi: 10.1021/acsnano.7b01493. [Epub ahead of print] PMID: 28524668 
  26. Mak M, Anderson S, McDonough MC, Spill F, Kim JE, Boussommier-Calleja A, Zaman MH, Kamm RD. Integrated Analysis of Intracellular Dynamics of MenaINV Cancer Cells in a 3D Matrix. Biophys J. 2017 May 9;112(9):1874-1884. doi: 10.1016/j.bpj.2017.03.030. PMID: 28494958 
  27. Akbari S, Pirbodaghi T, Kamm RD, Hammond PT.. A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation. Lab Chip. 2017 May 11. doi: 10.1039/c6lc01568a. [Epub ahead of print] PMID: 28492663 
  28. Funamoto K, Yoshino D, Matsubara K, Zervantonakis IK, Funamoto K, Nakayama M, Masamune J, Kimura Y, Kamm RD. Endothelial monolayer permeability under controlled oxygen tension. Integr Biol (Camb). 2017 Jun 19;9(6):529-538. doi: 10.1039/c7ib00068e. PMID: 28488717
  29. Pavesi A, Tan AT, Koh S, Chia A, Colombo M, …., Kamm RD, Bertoletti A. 2017. A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors. JCI Insight 2
  30. Abbas Y, Oefner CM, Polacheck WJ, Gardner L, Farrell L, Sharkey A, Kamm R, Moffett A, Oyen ML. A microfluidics assay to study invasion of human placental trophoblast cells.J R Soc Interface. 2017 May;14(130). pii: 20170131. doi: 10.1098/rsif.2017.0131.
  31. Kim, Min-Cheol; Abeyaratne, Rohan; Kamm, Roger D; Asada, H Harry. Dynamic modeling of cancer cell migration in an extracellular matrix fiber network. American Control Conference (ACC), 2017, 779-784, 2017
  32. Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palakurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Barzily-Rokni M, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, Izar B, Thakuria M, LeBoeuf NR, Rabinowits G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.Cancer Discov. 2017 Nov 3. pii: CD-17-0833. doi: 10.1158/2159-8290.CD-17-0833. [Epub ahead of print]
  33. Osaki T, Sivathanu V, Kamm RD. Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis. Biomaterials. 2017 Nov 25;156:65-76. doi: 10.1016/j.biomaterials.2017.11.041. [Epub ahead of print] PMID: 29190499
  34. Holle AW, Young JL, Van Vliet KJ, Kamm RD, Discher DE, Janmey PA, Spatz JP, Saif MT. Cell-ECM mechanobiology- forceful tools and emerging needs for basic and translational research. Nano Lett. 2017 Nov 27. doi: 10.1021/acs.nanolett.7b04982. [Epub ahead of print] PMID: 29178811
  35. Lee SWL, Adriani G, Ceccarello E, Pavesi A, Tan AT, Bertoletti A, Kamm RD, Wong SC. Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model. Front Immunol. 2018 Mar 6;9:416. doi: 10.3389/fimmu.2018.00416. eCollection 2018. PMID: 29559973 
  36. Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C, Kamm RD. The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model. Biomaterials. 2018 Mar 5. pii: S0142-9612(18)30164-9. doi: 10.1016/j.biomaterials.2018.03.005. [Epub ahead of print] PMID: 29548546
  37. Malandrino A, Kamm RD, Moeendarbary E. In Vitro Modeling of Mechanics in Cancer Metastasis. ACS Biomater Sci Eng. 2018 Feb 12;4(2):294-301. doi: 10.1021/acsbiomaterials.7b00041. Epub 2017 May 16. Review. PMID: 29457129 
  38. Kim MC, Silberberg YR, Abeyaratne R, Kamm RD, Asada HH. Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E390-E399. doi: 10.1073/pnas.1717230115. Epub 2018 Jan 2. PMID: 29295934
  39. Osaki T, Sivathanu V, Kamm RD. Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis. Biomaterials. 2018 Feb;156:65-76. doi: 10.1016/j.biomaterials.2017.11.041. Epub 2017 Nov 25. PMID: 29190499
  40. Holle AW, Young JL, Van Vliet KJ, Kamm RD, Discher D, Janmey P, Spatz JP, Saif T. Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research. Nano Lett. 2018 Jan 10;18(1):1-8. doi: 10.1021/acs.nanolett.7b04982. Epub 2017 Dec 6. PMID: 29178811 
  41. Conrad C, Götte M, Schlomann U, Roessler M, Pagenstecher A, Anderson P, Preston J, Pruessmeyer J, Ludwig A, Li R, Kamm RD, Ritz R, Carl B, Nimsky C, Bartsch JW. ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells. Int J Cancer. 2018 Feb 15;142(4):779-791. doi: 10.1002/ijc.31090. Epub 2017 Oct 31. PMID: 28986926
  42. Osaki T, Shin Y, Sivathanu V, Campisi M, Kamm RD. In Vitro Microfluidic Models for Neurodegenerative Disorders. Adv Healthc Mater. 2018 Jan;7(2). doi:10.1002/adhm.201700489. Epub 2017 Sep 7. Review. PMID: 28881425
  43. Pavesi A, Tan AT, Koh S, Chia A, Colombo M, Antonecchia E, Miccolis C, Ceccarello E, Adriani G, Raimondi MT, Kamm RD, Bertoletti A. A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors. JCI Insight. 2017 Jun 15;2(12). pii: 89762. doi: 10.1172/jci.insight.89762. [Epub ahead of print] PMID: 28614795 
  44. Akbari S, Pirbodaghi T, Kamm RD, Hammond PT. A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation. Lab Chip. 2017 Jun 13;17(12):2067-2075. doi: 10.1039/c6lc01568a. PMID: 28492663
  45. Han YL, Ronceray P, Xu G, Malandrino A, Kamm RD, Lenz M, Broedersz CP, Guo M. Cell contraction induces long-ranged stress stiffening in the extracellular matrix. Proc Natl Acad Sci U S A. 2018 Apr 4. pii: 201722619. doi: 10.1073/pnas.1722619115. [Epub ahead of print] PMID: 29618614 [PubMed - as supplied by publisher]
  46. Osaki T, Sivathanu V, Kamm RD. Engineered 3D vascular and neuronal networks in a microfluidic platform. Sci Rep. 2018 Mar 26;8(1):5168. doi: 10.1038/s41598-018-23512-1. PMID: 29581463
  47. Osaki, T., Serrano, J.C. & Kamm, R.D. Regen. Eng. Transl. Med. (2018). https://doi.org/10.1007/s40883-018-0054-2
  48. Osaki, T., Uzel, S. & Kamm, R.D., Microphysiological 3D model of Amyotrophic Lateral Sclerosis (ALS) from
  49. human iPS-derived muscle cells and optogenetic motor neurons, Science Adv, 2018.
  50. Fröse J, Chen MB, Hebron KE, Reinhardt F, Hajal C, Zijlstra A, Kamm RD, Weinberg RA. Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling. Cell Rep. 2018 Jul 24;24(4):962-972. doi: 10.1016/j.celrep.2018.06.092. PMID: 30044991 
  51. Yu YJ, Kim YH, Na K, Min SY, Hwang OK, Park DK, Kim DY, Choi SH, Kamm RD, Chung S, Kim JA. Hydrogel-incorporating unit in a well: 3D cell culture for high-throughput analysis.Lab Chip. 2018 Jul 25. doi: 10.1039/c8lc00525g. [Epub ahead of print]
  52. Adriani G, Pavesi A, Kamm RD. Studying TCR T cell anti-tumor activity in a microfluidic intrahepatic tumor model. Methods Cell Biol. 2018;146:199-214. doi: 10.1016/bs.mcb.2018.05.009. Epub 2018 Jul 12. PMID: 30037462
  53. Campisi M, Shin Y, Osaki T, Hajal C, Chiono V, Kamm RD. 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes. Biomaterials. 2018 Jul 12;180:117-129. doi: 10.1016/j.biomaterials.2018.07.014. [Epub ahead of print] PMID: 30032046 
  54. Li R, Serrano JC, Xing H, Lee TA, Azizgolshani H, Zaman M, Kamm RD. Interstitial Flow Promotes Macrophage Polarization toward an M2 Phenotype. Mol Biol Cell. 2018 Jul 11:mbcE18030164. doi: 10.1091/mbc.E18-03-0164. [Epub ahead of print] PMID: 29995595 

 

Patents

  • United States Patent 4,446,747 Kamm May 8, 1984 Method and apparatus for testing lip pressure applied to a smoking article and for calibrating the pressure testing apparatus
  • United States Patent 5,954,745 Gertler and Kamm, September 21, 1999
  • Catheter-filter set having a compliant seal (patent rights to Embolic Protection, Inc., subsequently purchased by Boston Scientific)
  • United States Patent 6,117,087 Kamm,  et al. September 12, 2000 Method and apparatus for noninvasive assessment of a subject's cardiovascular system
  • United States Patent 6,605,053 Kamm,  et al. August 12, 2003 Conduit designs and related methods for optimal flow control
  • PCT/US 20110159522 Application, Kamm et al., Filed April, 2008 Three-dimensional microfluidic platforms and methods of use thereof
  • Provisional patent application, Borenstein et al., October 6, 2009. Improvements to three-dimensional microfluidic platforms and methods of use thereof
  • PCT/US11/54029, Kamm et al., Filed October 19, 2010 Device for High Throughput Investigations of Multi-Cellular Interactions
  • United States Patent Application No. 13/743,223, Ragunath et. al., Filed January 16, 2013 Compositions and Methods for Neovasuclarization