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Roger Kamm

Contact Info

room NE47-321

Massachusetts Institute of Technology

77 Massachusetts Avenue

Cambridge, Masachusetts 02139


  • 1972


  • 1973


  • 1977



Research Interests

  • Microfluidics
  • Cell mechanics
  • Biological systems
  • Mechanotransduction
  • Tissue engineering
  • Metastatic cancer
  • Microvascular models

Honors + Awards

  • 2015    The Huiskes Medal (European Biomechanics Society) for lifetime of contributions
  • 2011    Honorary Member (American Venous Forum)
  • 2010    Fellow, AAAS
  • 2010    The Lissner Medal (ASME) for career contributions in bioengineering
  • 2010    Elected to the Institute of Medicine of the National Academies
  • 2005    Fellow, International Academy of Medical and Biological Engineering
  • 2004    Fellow, American Society of Mechanical Engineers
  • 2004    Fellow, Biomedical Engineering Society
  • 2002    Eschbach Distinguished Visiting Scholar Award, Northwestern University
  • 2001    Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching

Related Experience

  • 1986-1987 :      Senior Visiting Scientist, University of Cambridge, Department of Applied Mathematics and Theoretical Physics. Visiting Fellow, Clare Hall, University of Cambridge


  • American Society of Mechanical Engineers
  • Biomedical Engineering Society
  • America Association for the Advancement of Science
  • American Institute of Medical and Biological Engineering
  • European Biomechanics Society
  • International Academy of Medical and Biological Engineering
  • American Venous Forum
  • National Academy of Medicine

Professional Service

  • Editorial Boards: Journal of Multiscale Modeling, Cellular and Molecular Bioengineering, Methods in Cell Science, Cellular and Molecular Bioengineering, Biomedical Engineering Letters, Journal Royal Society Interface
  • 2014      Chair, World Congress of Biomechanics
  • 2011 – 2015    Chair, International Academy of Medical & Biological Engineers
  • 2007 – 2010    Director, Global Enterprise for MicroMechanics and Molecular Medicine
  • 2004 – 2009    Hypertension and Microcirculation Study Section (regular member)
  • 2003 – 2008    BMES Publications Board (Chair, 2004 – 2006), Board of Directors (2005 – 2008)
  • 2001    Chair, Summer Bioengineering Conference, Snowbird Utah
  • 1998 – 2018    World Council on Biomechanics (Vice Chair, 2002-2006, Chair, 2006-2010)
  • 1997 – 2009    US National Committee on Biomechanics (Secretary-treasurer, 2000 – 03, Vice Chair, 2003 – 2006, Chair, 2006-2009)


  • Molecular, Cellular and Tissue Biomechanics (20.310, 20.410, 2.797, 2.798)
  • Fields, Forces and Flows in Biological Systems (20.430, 2.795)


Publications in the past 3 years:

  • Bai J, Adriani G, Dang TM, Tu TY, Penny HL, Wong SC, Kamm RD, Thiery JP. Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions. Oncotarget. 2015 Jul 30. [Epub ahead of print] PMID: 26231039
  • Chung EY, Ochs CJ, Wang Y, Lei L, Qin Q, Smith AM, Strongin AY, Kamm R, Qi YX, Lu S, Wang Y. Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells. Nano Lett. 2015 Jul 27. [Epub ahead of print] PMID: 26203778
  • Pavesi A, Adriani G, Rasponi M, Zervantonakis IK, Fiore GB, Kamm RD. Controlled electromechanical cell stimulation on-a-chip. Sci Rep. 2015 Jul 2;5:11800. doi: 10.1038/srep11800. PMID: 26135970
  • Mak M, Kim T, Zaman MH, Kamm RD. Multiscale mechanobiology: computational models for integrating molecules to multicellular systems. Integr Biol (Camb). 2015 May 27. [Epub ahead of print] PMID: 26019013
  • Bidone TC, Kim T, Deriu MA, Morbiducci U, Kamm RD. Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks. Biomech Model Mechanobiol. 2015 Feb 24. [Epub ahead of print] PMID: 25708806
  • Giuliano Scarcelli, William J Polacheck, Hadi T Nia, Kripa Patel, Alan J Grodzinsky, Roger D Kamm, Seok Hyun Yun, Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy, Nature Methods, 2015
  • Min-Cheol Kim, Jordan Whisler, Yaron R Silberberg, Roger D Kamm, H Harry Asada, Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network, PLoS Comput Biol, 11(10), e1004535, 2015
  • J Bai, TY Tu, C Kim, JP Thiery, RD Kamm, dentification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment. Oncotarget, 2015
  • Giovanni Stefano Ugolini, Marco Rasponi, Andrea Pavesi, Rosaria Santoro, Roger Kamm, Gianfranco Beniamino Fiore, Maurizio Pesce, Monica Soncini. On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain. Biotechnology and bioengineering, 2015
  • Jing Bai, Giulia Adriani, Truong-Minh Dang, Ting-Yuan Tu, HX Penny, Siew-Cheng Wong, Roger D Kamm, Jean-Paul Thiery. Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions. Oncotarget 6 (28), 25295-25307, 2015
  • Ochs CJ, Kasuya J, Pavesi A and Kamm RD, Oxygen levels in thermoplastic microfluidic devices during cell culture, Lab Chip, 2014, 14 (3), 459 - 462, DOI:10.1039/C3LC51160J
  • Bersini S, Jeon JS, Dubini G, Arrigoni C, Charest JL, Moretti M, Kamm RD, A mircrofluidic 3D in vitro model for specificity of breast cancer metastasis to bone, Biomaterials. 2014 Mar;35(8):2454-61. doi: 10.1016/j.biomaterials.2013.11.050. Epub 2013 Dec 31. PMID: 24388382
  • Park YK, Tu TY, Lim SH, Clement IJM, Yang SY, Roger D. Kamm RD, In Vitro Microvessel Growth and Remodeling within a Three-dimensional Microfluidic Environment, Cell Mol Bioeng. 2014 Mar 1;7(1):15-25. PMID: 24660039 [PubMed]
  • Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD. Mechanotransduction of fluid stresses governs 3D rheotaxis, Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2447-52. doi: 10.1073/pnas.1316848111. Epub 2014 Feb 3. PMID: 24550267
  • Tang D, Kamm RD, Yang C, Zheng J, Canton G, Bach R, Huang X, Hatsukami TS, Zhu J, Ma G, Maehara A, Mintz GS, Yuan C. Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: Data, modeling, validation, uncertainty and predictions. J Biomech. 2014 Mar 3;47(4):834-46. doi: 10.1016/j.jbiomech.2014.01.012. Epub 2014 Jan 14. PMID: 24480706 [PubMed - in process]
  • Niu Y, Bai J, Kamm RD, Wang Y, Wang C. Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment. Mol Pharm. 2014 Jul 7;11(7):2022-9. doi: 10.1021/mp500054h. Epub 2014 Feb 24. PMID: 24533867 [PubMed - in process]
  • Jeon JS, Bersini S, Whisler JA, Chen MB, Dubini G, Charest JL, Moretti M, Kamm RD.  Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb). 2014 May;6(5):555-63. doi: 10.1039/c3ib40267c. PMID: 24676392
  • Bao G, Bazilevs Y, Chung JH, Decuzzi P, Espinosa HD, Ferrari M, Gao H, Hossain SS, Hughes TJ, Kamm RD, Liu WK, Marsden A, Schrefler B. USNCTAM perspectives on mechanics in medicine. J R Soc Interface. 2014 Aug 6;11(97):20140301. doi: 10.1098/rsif.2014.0301. PMID: 24872502 [PubMed - in process]
  • Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL. Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells. Stem Cell Rev. 2014 Sep 5. [Epub ahead of print] PMID: 25190668
  • Uzel SG, Pavesi A, Kamm RD. Microfabrication and microfluidics for muscle tissue models. Prog Biophys Mol Biol. 2014 Aug 28. pii: S0079-6107(14)00088-1. doi: 10.1016/j.pbiomolbio.2014.08.013. [Epub ahead of print] PMID: 25175338
  • Borau C, Polacheck WJ, Kamm RD, Garcia-Aznar JM. Probabilistic voxel-fe model for single cell motility in 3D. In Silico Cell and Tissue Science, 1:2, 2014.
  • Mak M, Kamm RD, Zaman MH. Impact of Dimensionality and Network Disruption on Microrheology of Cancer Cells in 3D Environments. PLoS Comput Biol. 2014 Nov 20;10(11):e1003959. doi: 10.1371/journal.pcbi.1003959. eCollection 2014 Nov, PMID: 25412385
  • Kim C, Kasuya J, Jeon J, Chung S, Kamm. A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs. Lab Chip. 2014 Dec 3;15(1):301-10. doi: 10.1039/c4lc00866a. PMID: 25370780
  • Jeon, Jessie S; Bersini, Simone; Gilardi, Mara; Dubini, Gabriele; Charest, Joseph L; Moretti, Matteo; Kamm, Roger D; Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation, Proceedings of the National Academy of Sciences, pp. 201417115, 2014
  • Borau, Carlos; Kamm, Roger D; Garci¬a-Aznar, Jose Manuel; A time-dependent phenomenological model for cell mechano-sensing, Biomechanics and modeling in mechanobiology. 13(2): 451-462, 2014
  • Aref AR, Huang RY-J, Yu W, Chua K-N, Sun W, Tu T-Y, Sim W-J, Zervantonakis IK, Thiery JP, Kamm RD. Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb). 2013 Feb;5(2):381-9. doi: 10.1039/c2ib20209c PMID: 23172153 [PubMed - indexed for MEDLINE]
  • Rimchala T, Kamm RD, Lauffenburger DA. Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines. Integr Biol (Camb). 2013 Jan 10. [Epub ahead of print]  PMID: 23303249
  • Jeon JS, Zervantonakis IK, Chung S, Kamm RD, Charest JL. In vitro model of tumor cell extravasation. PLoS One. 2013;8(2):e56910. doi: 10.1371/journal.pone.0056910. Epub 2013 Feb 20. PMID: 23437268
  • Hammond NA, Kamm RD. Mechanical characterization of self-assembling peptide hydrogels by microindentation. J Biomed Mater Res B Appl Biomater. 2013 Mar 26. doi: 10.1002/jbm.b.32906.  PMID: 23529940
  • Liu F, Wu D, Kamm RD, Chen K. Analysis of nanoprobe penetration through a lipid bilayer. Biochim Biophys Acta. 2013 Mar 20. doi:pii: S0005-2736(13)00074-6. 10.1016/j.bbamem.2013.03.011. PMID: 23524226
  • Kim MC, Neal DM, Kamm RD, Asada HH. Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol. 2013 Feb;9(2):e1002926. doi: 10.1371/journal.pcbi.1002926. Epub 2013 Feb 28.
  • Hammond NA, Kamm RD. Mechanical characterization of self-assembling peptide hydrogels by microindentation. J Biomed Mater Res B Appl Biomater. 2013 Aug;101(6):981-90. doi: 10.1002/jbm.b.32906. Epub 2013 Mar 26. PMID: 23529940
  • Kothapalli CR, Kamm RD. 3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages. Biomaterials. 2013 Aug;34(25):5995-6007. doi: 10.1016/j.biomaterials.2013.04.042. Epub 2013 May 18. PMID: 23694902
  • Polacheck WJ, Li R, Uzel SG, Kamm RD. Microfluidic platforms for mechanobiology. Lab Chip. 2013 Jun 21;13(12):2252-67. doi: 10.1039/c3lc41393d. Epub 2013 May 7. PMID: 23649165
  • Hesse WR, Steiner M, Wohlever ML, Kamm RD, Hwang W, Lang MJ. Modular aspects of kinesin force generation machinery. Biophys J. 2013 May 7;104(9):1969-78. doi: 10.1016/j.bpj.2013.03.051.
  • Borau C, Kamm RD, García-Aznar JM. A time-dependent phenomenological model for cell mechano-sensing. Biomech Model Mechanobiol. 2013 Jun 20. [Epub ahead of print]
  • Kamm RD, Bashir R. Creating Living Cellular Machines. Ann Biomed Eng. 2013 Sep 5. [Epub ahead of print] PMID: 24006130
  • Chen MB, Whisler JA, Jeon JS, Kamm RD. Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. Integr Biol (Camb). 2013 Sep 23; 5(10):1262-71. doi: 10.1039/c3ib40149a. PMID: 23995847
  • Rahim NAA, Pelet S, Mofrad MRK, So PTC, Kamm RD, Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy, Methods (2013), doi:
  • Kim MC, Neal DM, Kamm RD, Asada HH, Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol. 2013;9(2):e1002926. doi: 10.1371/journal.pcbi.1002926. Epub 2013 Feb 28.
  • Lim SH, Kim C, Aref AR, Kamm RD, Raghunath M, Complementary effects of ciclopirox olamine, a prolyl-hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary
  • sprouting, Integr Biol (Camb), 2013, DOI: 10.1039/c3ib40082d.
  • Tu TY, Wang Z, Bai J, Sun W, Peng WK, Huang RY, Thiery JP, Kamm RD Rapid Prototyping of Concave Microwells for the Formation of 3D Multicellular Cancer Aggregates for Drug Screening. Adv Healthcare Mater. 2013 Aug 27. doi: 10.1002/adhm.201300151. PMID: 23983140
  • Whisler JA, Chen MB, Kamm RD. Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System. Tissue Eng Part C Methods. 2014 Jul;20(7):543-52. doi: 10.1089/ten.TEC.2013.0370. Epub 2013 Dec 13. PMID: 24151838
  • Abdul Rahim NA, Pelet S, Mofrad MRK, So PTC, Kamm RD, Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy, Methods. 2014 Mar 15;66(2):208-21. doi: 10.1016/j.ymeth.2013.10.007. Epub 2013 Oct 31. PMID: 24184188
  • Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA, Vascular Endothelial Growth Factor and Platelet Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context. Mol Cell Proteomics. 2013 Dec;12(12):3704-18. doi: 10.1074/mcp.M113.030528. Epub 2013 Sep 9. PMID: 24023389
  • Bersini S, Jeon JS, Moretti M, Kamm RD. In vitro models of the metastatic cascade: from local invasion to extravasation. Drug Discov Today. 2013 Dec 17. pii: S1359-6446(13)00424-8. doi: 10.1016/j.drudis.2013.12.006. [Epub ahead of print] PMID: 24361339
  • Rahim NA, Pelet S, Kamm RD, So PT. Methodological considerations for global analysis of cellular FLIM/FRET measurements. J Biomed Opt. 2012 Feb;17(2):026013.
  • Wong KH, Chan JM, Kamm RD, Tien J. Microfluidic Models of Vascular Functions. Annu Rev Biomed Eng. 2012 Apr 23. [Epub ahead of print]
  • Farahat WA, Wood LB, Zervantonakis IK, Schor A, Ong S, Neal D, Kamm RD, Asada H. Ensemble Analysis of Angiogenic Growth in Three-Dimensional Microfluidic Cell Cultures, PLoS One, 7(5), 2012. PMID: 22662145
  • Yuchun Liu, Swee-Hin Teoh, Mark SK Chong, Eddy SM Lee, Citra N Mattar, Nau’shil K Randhawa, Zhiyong Zhang, Roger D Kamm, Nicholas M Fisk, Mahesh Choolani, Jerry K Y Chan. Vasculogenic and Osteogenesis-Enhancing Potential of Human Umbilical Cord Blood Endothelial Colony-Forming Cells. Stem Cells (2012) 2012 Jul 3. doi: 10.1002/stem.1164. PMID: 22761003
  • Choong Kim, Seok Chung, Liu Yuchun, Min-Cheol Kim Jerry K. Y. Chan, H. Harry Asada and Roger D. Kamm In vitro angiogenesis assay for the study of cell encapsulation therapy. Lab Chip, 2012, DOI:10.1039/C2LC40182G PMID: 22722695
  • Shin Y, Han S, Jeon JS, Yamamoto K, Zervantonakis IK, Sudo R, Kamm RD and Chung S. Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels.  Nature Prot, 7(7):1247-1259, 2012, PMID: 22678430
  • Vickerman V, Kamm RD. Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions. Integr Biol (Camb). 2012 Jun 7. PMID 22722695
  • Wood LB, Ge R, Kamm RD, Asada HH. Nascent vessel elongation rate is inversely related to diameter in in vitro angiogenesis, Integr. Biol., 2012, DOI: 10.1039/C2IB20054F
  • Zervantonakis IK, Hughes-Alford SK, Charest JL, Condeelis JS, Gertler FB, Kamm RD.  Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.  Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13515-20. Epub 2012 Aug 6. PMID: 22869695
  • Funamoto K, Zervantonakis IK, Liu Y, Ochs CJ, Kim C, Kamm RD.  A Novel Microfluidic Platform for High-Resolution Imaging of a Three-Dimensional Cell Culture under a Controlled Hypoxic Environment, Lab Chip, DOI: 10.1039/c0xx00000x
  • Tharin S, Kothapali CR, Ozdinler PH, Pasquina L, Chung S, Varner J, DeValance S, Kamm R, Macklis JD A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes. Integr Biol, 4, 1398-1405, 2012, DOI: 10.1039/c2ib20019h
  • Polacheck WJ, Zervantonakis IK, Kamm RD. Tumor cell migration in complex microenvironments, Cell Mol Life Sci, 2012, DOI 10.1007/s00018-012-1115-1
  • Kim MC, Kim C, Wood L, Neal D, Kamm RD, Asada HH. Integrating focal adhesion dynamics, cytoskeleton remodeling, and actin motor activity for predicting cell migration on 3D curved surfaces of the extracellular matrix. Integr Biol (Camb). 2012 Sep 18. [Epub ahead of print]
  • Sakar MS, Neal D, Boudou T, Borochin MA, Li Y, Weiss R, Kamm RD, Chen CS, Asada HH. Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. Lab Chip. 2012 Dec. 7; 12(23): 4976-85. Doi: 10.1039/c2lc40338b.
  • Borau C, Kim TY, Bidone T, García-Aznar JM, Kamm  RD, Dynamic Mechanisms of Cell Rigidity Sensing: Insights from a Computational Model of Actomyosin Networks, PLoS ONE, PONE-D-12-23235R1
  • Chan JM, Zervantonakis IK, Rimchala T, Polacheck WJ, Whisler J, Kamm RD. Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting. PLoS ONE, 2012;7(12):e50582. doi: 10.1371/journal.pone.0050582. PMID: 23226527
  • Shin Y, Kim H, Han S, Won J, Lee E-S, Kamm RD, Kim J-H, Chung S. Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion, Adv Healthc Mater. 2013 Jun;2(6):790-4. doi: 10.1002/adhm.201200320. Epub 2012 Nov 26. PMID: 23184641
  • Han S, Yan JJ, Shin Y, Jeon JJ, Won J, Jeong HE, Kamm RD, Kim YJ, Chung S A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils. Lab Chip. 2012 Oct 21;12(20):3861-5. PMID: 22903230
  • Kalchman J, Fujioka S, Chung S, Kikkawa Y, Mitaka T, Kamm RD, Tanishita K, Sudo R. A Three-Dimensional Microfluidic Tumor Cell Migration Assay to Screen the Effect of Anti-Migratory Drugs and Interstitial Flow. Microfluid Nanofluid, 2012,  DOI 10.1007/s10404-012-1104-6


  • United States Patent 4,446,747 Kamm May 8, 1984 Method and apparatus for testing lip pressure applied to a smoking article and for calibrating the pressure testing apparatus
  • United States Patent 5,954,745 Gertler and Kamm, September 21, 1999
  • Catheter-filter set having a compliant seal (patent rights to Embolic Protection, Inc., subsequently purchased by Boston Scientific)
  • United States Patent 6,117,087 Kamm,  et al. September 12, 2000 Method and apparatus for noninvasive assessment of a subject's cardiovascular system
  • United States Patent 6,605,053 Kamm,  et al. August 12, 2003 Conduit designs and related methods for optimal flow control
  • PCT/US 20110159522 Application, Kamm et al., Filed April, 2008 Three-dimensional microfluidic platforms and methods of use thereof
  • Provisional patent application, Borenstein et al., October 6, 2009. Improvements to three-dimensional microfluidic platforms and methods of use thereof
  • PCT/US11/54029, Kamm et al., Filed October 19, 2010 Device for High Throughput Investigations of Multi-Cellular Interactions
  • United States Patent Application No. 13/743,223, Ragunath et. al., Filed January 16, 2013 Compositions and Methods for Neovasuclarization