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Professor
Scott Manalis
David H. Koch (1962) Professor in Engineering
Interests
- Single cell analysis
- Microfluidics
- Micro- and nanomechanical resonators
Professor Manalis News + Media
Acoustic waves can monitor stiffness of living cells
MIT engineers, including Professor Scott Manalis, have devised a new, noninvasive way to measure the stiffness of living cells using acoustic waves. The technique could be useful for precision medicine.
Measuring cancer cell “fitness” reveals drug susceptibility
New research from Professor Scott Manalis on the physical and genomic features of cancer cells could be used to reveal new drug targets that would make cancer treatment more effective.
Microchip enables fast, precise measurement of single-cell growth
Professor Scott Manalis invents new technique that can precisely measure the growth of many individual cells simultaneously, and could lead to rapid tests for antibiotics.
Faculty Details
Education
-
1994
UNIVERSITY OF CALIFORNIA-SANTA BARBARA
B.Sc. -
1998
STANFORD UNIVERSITY
Ph.D.
Research Interests
High precision measurement for biological systems
Honors + Awards
- 2002, Presidential Early Career Award for Scientists and Engineers, AFOSR
- 2002, MIT Technology Review TR100
- 2009, Baker Award for Excellence in Undergraduate Teaching
- 2013, Elected to College of Fellows, American Institute for Medical and Biological Engineering
- 2014, Appointed the Andrew and Erna Viterbi Professor of Biological Engineering
Teaching
- Fields, Forces and Flows in Biological Systems (2.793)
- Instrumentation and Measurement for Biological Systems (2.673)
Publications
- Olcum S, Cermak N, Wasserman SC, Christine KS, Atsumi H, Payer KR, Shen WJ, Lee JC, Belcher AM, Bhatia SN, Manalis SR. (2014). Weighing nanoparticles in solution at the attogram scale. Proceedings of the National Academy of Sciences of the United States of America, 111(4): 1310-5.
- Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, Manalis SR. (2013). Characterizing deformability and surface friction of cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 110(19): 7580-5.
- Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR. (2012). Direct observation of mammalian cell growth and size regulation. Nature Methods, 9(9): 910-+.
- Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR. (2011). Measuring single-cell density. Proceedings of the National Academy of Sciences of the United States of America, 108(27): 10992-6.
- Burg TP, Sader JE, Manalis SR. (2009). Nonmonotonic Energy Dissipation in Microfluidic Resonators. Physical Review Letters, 102(22).
- Squires TM, Messinger RJ, Manalis SR. (2008). Making it stick: convection, reaction and diffusion in surface-based biosensors. Nature Biotechnology, 26(4): 417-26.
- Burg TP, Godin M, KFields, Forces and Flows in Biological Systems (2.793)
Instrumentation and Measurement for Biological Systems (2.673)nudsen SM, Shen W, Carlson G, Foster JS, Babcock K, Manalis SR. (2007). Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature, 446(7139): 1066-9.