Professor of Biological and Mechanical Engineering; Cecil and Ida Green Distinguished Professor; Singapore Research Professor
A microfluidic tissue model developed by Professor Roger Kamm finds that Alzheimer’s damage allows toxins to enter the brain, further harming neurons.
Professor Roger Kamm has developed a microfluidic chip containing the first 3-D human tissue model of the interface between motor neurons and muscle fibers. The chip could help researchers test ALS drugs.
MechE researchers across a diverse range of specialties are developing new and innovative ways to deepen our understanding of disease and unlock new therapies to treat it.
NORTHWESTERN UNIVERSITY
B.Sc.MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)
M.Sc.MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)
Ph.D.Recent Publications in the past 2 years:
Lee SWL, Campisi M, Osaki T, Possenti L, Mattu C, Adriani G, Kamm RD, Chiono V. Modeling Nanocarrier Transport across a 3D In Vitro Human Blood-Brain-Barrier Microvasculature. Adv Healthc Mater. 2020 Mar 3:e1901486. doi: 10.1002/adhm.201901486. [Epub ahead of print] PMID: 32125776
Lee SWL, Adriani G, Kamm RD, Gillrie MR. Models for Monocytic Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1224:87-115. doi: 10.1007/978-3-030-35723-8_7. Review. PMID: 32036607
Sun W, Starly B, Daly AC, Burdick JA, Groll J, Skeldon G, Shu W, Sakai Y, Shinohara M, Nishikawa M, Jang J, Cho DW, Nie M, Takeuchi S, Ostrovidov S, Khademhosseini A, Kamm RD, Mironov V, Moroni L, Ozbolat IT. The bioprinting roadmap. Biofabrication. 2020 Feb 6;12(2):022002. doi: 10.1088/1758-5090/ab5158. PMID: 32031083
Koens R, Tabata Y, Serrano JC, Aratake S, Yoshino D, Kamm RD, Funamoto K. Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension. APL Bioeng. 2020 Mar 6;4(1):016106. doi: 10.1063/1.5127069. eCollection 2020 PMID: 32161836 [PubMed]
Offeddu, Giovanni S; Shin, Yoojin; Kamm, Roger D; Microphysiological models of neurological disorders for drug development. Current Opinion in Biomedical Engineering, 13, 119-126, 2020
Osaki, Tatsuya; Uzel, Sebastien GM; Kamm, Roger D; On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Nature protocols, 152, 421-449, 2020
Coughlin, Mark F; Kamm, Roger D; The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation, Advanced Healthcare Materials, 9, 8, 1901410, 2020
Lee, Sharon Wei Ling; Seager, RJ; Litvak, Felix; Spill, Fabian; Sieow, Je Lin; Leong, Penny Hweixian; Kumar, Dillip; Tan, Alrina Shin Min; Wong, Siew Cheng; Adriani, Giulia; Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment. Integrative Biology, 12, 4, 90-108, 2020
Shelton, Sarah E; Kamm, Roger D; In vitro, primarily microfluidic models for atherosclerosis, Biomechanics of Coronary Atherosclerotic Plaque,303-319, 2020
Ross Ethier, C; Caro, Colin G; Diller, Kenneth R; Guldberg, Robert E; Kamm, Roger D; Platt, Manu O; Yoganathan, Ajit P; In Memoriam Robert M. Nerem, 1937–2020. Journal of Biomechanical Engineering, 142, 6, 2020
Haase, Kristina; Offeddu, Giovanni S; Gillrie, Mark R; Kamm, Roger D; Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model. Advanced Functional Materials, 200244, 2020
Bai J, Khajavi M, Sui L, Fu H, Tarakkad Krishnaji S, Birsner AE, Bazinet L, Kamm RD, D'Amato RJ. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes. Angiogenesis. 2020 Sep 21. doi: 10.1007/s10456-020-09746-6. PMID: 32955682
SWL Lee, M Campisi, T Osaki, L Possenti, C Mattu, G Adriani, RD Kamm, ... Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature. Advanced Healthcare Materials 9 (7), 1901486
Campisi M, Sundararaman SK, Shelton SE, Knelson EH, Mahadevan NR, Yoshida R, Tani T, Ivanova E, Cañadas I, Osaki T, Lee SWL, Thai T, Han S, Piel BP, Gilhooley S, Paweletz CP, Chiono V, Kamm RD, Kitajima S, Barbie DA. Tumor-Derived cGAMP Regulates Activation of the Vasculature. Front Immunol. 2020 Sep 4;11:2090. doi: 10.3389/fimmu.2020.02090. eCollection 2020.
Garreta E, Kamm RD, Chuva de Sousa Lopes SM, Lancaster MA, Weiss R, Trepat X, Hyun I, Montserrat. Rethinking organoid technology through bioengineering. Nat Mater. 2020 Nov 16. doi: 10.1038/s41563-020-00804-4.
Douglas SA, Haase K, Kamm RD, Platt MO. Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche. APL Bioeng. 2020 Nov 4;4(4):046102. doi: 10.1063/5.0023342. eCollection 2020 Dec.
Bai, J., Haase, K., Roberts, J.J., Hoffmann, J., Nguyen, H.T., Wan, Z., Zhang, S., Sarker, B., Friedman, N., Ristić-Lehmann, Č. and Kamm, R.D., 2020. A novel 3D vascular assay for evaluating angiogenesis across porous membranes. Biomaterials, p.120592.
Shelton, S.E., Nguyen, H.T., Barbie, D.A. and Kamm, R.D., 2020. Engineering approaches for studying immune-tumor cell interactions and immunotherapy. iScience, p.101985.
Hajal C, Ibrahim L, Serrano JC, Offeddu GS, Kamm RD. The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform. Biomaterials. 2021 Jan;265:120470. doi: 10.1016/j.biomaterials.2020.120470. Epub 2020 Oct 19. PMID: 33190735
Zhang, S., Wan, Z. and Kamm, R.D., 2021. Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature. Lab on a Chip, 21(3), pp.473-488.
Kamm, R.D., 2021. Toward improved models of human cancer: Two perspectives. APL Bioeng. 2021 Feb 19;5(1):010402. doi: 10.1063/5.0042324. eCollection 2021 Mar. PMID: 33644625
Offeddu, G.S., Serrano, J.C., Chen, S.W., Shelton, S.E., Shin, Y., Floryan, M. and Kamm, R.D., 2021. Microheart: A microfluidic pump for functional vascular culture in microphysiological systems. Journal of Biomechanics, 2021 Feb 14;119:110330. doi: 10.1016/j.jbiomech.2021.110330. PMID: 33631662
Offeddu, G.S., Hajal, C., Foley, C.R., Wan, Z., Ibrahim, L., Coughlin, M.F. and Kamm, R.D., 2021. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination. Communications Biology, 4(1), pp.1-10. PMID: 33631662
Bai, J., Khajavi, M., Sui, L., Fu, H., Krishnaji, S.T., Birsner, A.E., Bazinet, L., Kamm, R.D. and D’Amato, R.J., 2021. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes. Angiogenesis, 24(1), pp.111-127.
Roberts, A.B., Zhang, J., Singh, V.R., Nikolić, M., Moeendarbary, E., Kamm, R.D., So, P.T. and Scarcelli, G., 2021. Tumor cell nuclei soften during transendothelial migration. Journal of Biomechanics, 121, p.110400.
Hajal, C., Le Roi, B., Kamm, R.D. and Maoz, B.M., 2021. Biology and Models of the Blood–Brain Barrier. Annual Review of Biomedical Engineering, 23, pp.359-384.
Serrano, J.C., Gupta, S.K., Kamm, R.D. and Guo, M., 2021. In pursuit of designing multicellular engineered living systems: A fluid mechanical perspective. Annual Review of Fluid Mechanics, 53, pp.411-437.
Hajal, C., Shin, Y., Li, L., Serrano, J.C., Jacks, T. and Kamm, R.D., 2021. The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain. Science Advances, 7(26), p.eabg8139.
Gilardi, M., Bersini, S., Valtorta, S., Proietto, M., Crippa, M., Boussommier-Calleja, A., Labelle, M., Moresco, R.M., Vanoni, M., Kamm, R.D. and Moretti, M., 2021. The driving role of the Cdk5/Tln1/FAKS732 axis in cancer cell extravasation dissected by human vascularized microfluidic models. Biomaterials, p.120975.
Wan, Z., Zhang, S., Zhong, A.X., Shelton, S.E., Campisi, M., Sundararaman, S.K., Offeddu, G.S., Ko, E., Ibrahim, L., Coughlin, M.F. and Liu, T., 2021. A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts. Biomaterials, p.121032.
Vila, O.F., Chavez, M., Ma, S.P., Yeager, K., Zholudeva, L.V., Colón-Mercado, J.M., Qu, Y., Nash, T.R., Lai, C., Feliciano, C.M. and Carter, M., 2021. Bioengineered optogenetic model of human neuromuscular junction. Biomaterials, 276, p.121033.
Grass, M., McDougal, A.D., Blazeski, A., Kamm, R.D., García-Cardeña, G. and Dewey Jr, C.F., 2022. A computational model of cardiomyocyte metabolism predicts unique reperfusion protocols capable of reducing cell damage during ischemia/reperfusion. Journal of Biological Chemistry, p.101693.
Maurissen, T.L., Pavlou, G., Bichsel, C., Villaseñor, R., Kamm, R.D. and Ragelle, H., 2022. Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature. Journal of Personalized Medicine, 12(2), p.148.
Kim, M.C., Li, R., Abeyaratne, R., Kamm, R.D. and Asada, H.H., 2022. A computational modeling of invadopodia protrusion into an extracellular matrix fiber network. Scientific Reports, 12(1), pp.1-19.
Hajal, C., Offeddu, G.S., Shin, Y., Zhang, S., Morozova, O., Hickman, D., Knutson, C.G. and Kamm, R.D., 2022. Engineered human blood–brain barrier microfluidic model for vascular permeability analyses. Nature protocols, pp.1-34.