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Roger Kamm

Contact Info

room NE47-321

Massachusetts Institute of Technology

77 Massachusetts Avenue

Cambridge, Massachusetts 02139

Education

  • 1972

    NORTHWESTERN UNIVERSITY

    B.Sc.
  • 1973

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)

    M.Sc.
  • 1977

    MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)

    Ph.D.

Research Interests

  • Microfluidics
  • Cell mechanics
  • Biological systems
  • Neurologicasl disease
  • Tissue engineering
  • Metastatic cancer
  • Microvascular models

Honors + Awards

  • 2020    Shu Chien Achievement Award (BMES CMBE), for contributions to the field of cellular and molecular bioengineering
  • 2018    The Nerem Medal (ASME) for excellence in education and mentoring
  • 2015    The Huiskes Medal (European Biomechanics Society) for lifetime of contributions
  • 2011    Honorary Member (American Venous Forum)
  • 2010    Fellow, AAAS
  • 2010    The Lissner Medal (ASME) for career contributions in bioengineering
  • 2010    Elected to the Institute of Medicine of the National Academies
  • 2005    Fellow, International Academy of Medical and Biological Engineering
  • 2004    Fellow, American Society of Mechanical Engineers
  • 2004    Fellow, Biomedical Engineering Society
  • 2002    Eschbach Distinguished Visiting Scholar Award, Northwestern University
  • 2001    Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching

Memberships

  • American Society of Mechanical Engineers
  • Biomedical Engineering Society
  • America Association for the Advancement of Science
  • American Institute of Medical and Biological Engineering
  • European Biomechanics Society
  • International Academy of Medical and Biological Engineering
  • American Venous Forum
  • National Academy of Medicine

Professional Service

  • Editorial Boards: Journal of Multiscale Modeling, Cellular and Molecular Bioengineering, Methods in Cell Science, Cellular and Molecular Bioengineering, Biomedical Engineering Letters, Journal Royal Society Interface
  • 2010 - 2020    Director, NSF Center on Emergent Behaviors of Integrated Cellular Systems
  • 2014                Chair, World Congress of Biomechanics
  • 2011 – 2015    Chair, International Academy of Medical & Biological Engineers
  • 2007 – 2010    Director, Global Enterprise for MicroMechanics and Molecular Medicine
  • 2004 – 2009    Hypertension and Microcirculation Study Section (regular member)
  • 2003 – 2008    BMES Publications Board (Chair, 2004 – 2006), Board of Directors (2005 – 2008)
  • 2001                Chair, Summer Bioengineering Conference, Snowbird Utah
  • 1998 – 2018    World Council on Biomechanics (Vice Chair, 2002-2006, Chair, 2006-2010)
  • 1997 – 2009    US National Committee on Biomechanics (Secretary-treasurer, 2000 – 03, Vice Chair, 2003 – 2006, Chair, 2006-2009)

Teaching

  • Molecular, Cellular and Tissue Biomechanics (20.310, 20.410, 2.797, 2.798)
  • Fields, Forces and Flows in Biological Systems (20.430, 2.795)

Publications

Recent Publications in the past 2 years:

Lee SWL, Campisi M, Osaki T, Possenti L, Mattu C, Adriani G, Kamm RD, Chiono V. Modeling Nanocarrier Transport across a 3D In Vitro Human Blood-Brain-Barrier Microvasculature. Adv Healthc Mater. 2020 Mar 3:e1901486. doi: 10.1002/adhm.201901486. [Epub ahead of print] PMID: 32125776

Lee SWL, Adriani G, Kamm RD, Gillrie MR. Models for Monocytic Cells in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1224:87-115. doi: 10.1007/978-3-030-35723-8_7. Review. PMID: 32036607

Sun W, Starly B, Daly AC, Burdick JA, Groll J, Skeldon G, Shu W, Sakai Y, Shinohara M, Nishikawa M, Jang J, Cho DW, Nie M, Takeuchi S, Ostrovidov S, Khademhosseini A, Kamm RD, Mironov V, Moroni L, Ozbolat IT. The bioprinting roadmap. Biofabrication. 2020 Feb 6;12(2):022002. doi: 10.1088/1758-5090/ab5158. PMID: 32031083

Koens R, Tabata Y, Serrano JC, Aratake S, Yoshino D, Kamm RD, Funamoto K. Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension. APL Bioeng. 2020 Mar 6;4(1):016106. doi: 10.1063/1.5127069. eCollection 2020 PMID: 32161836 [PubMed]

Offeddu, Giovanni S; Shin, Yoojin; Kamm, Roger D; Microphysiological models of neurological disorders for drug development. Current Opinion in Biomedical Engineering, 13, 119-126, 2020

Osaki, Tatsuya; Uzel, Sebastien GM; Kamm, Roger D; On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Nature protocols, 152, 421-449, 2020

Coughlin, Mark F; Kamm, Roger D;  The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation, Advanced Healthcare Materials, 9, 8, 1901410, 2020

Lee, Sharon Wei Ling; Seager, RJ; Litvak, Felix; Spill, Fabian; Sieow, Je Lin; Leong, Penny Hweixian; Kumar, Dillip; Tan, Alrina Shin Min; Wong, Siew Cheng; Adriani, Giulia; Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment. Integrative Biology, 12, 4, 90-108, 2020

Shelton, Sarah E; Kamm, Roger D; In vitro, primarily microfluidic models for atherosclerosis, Biomechanics of Coronary Atherosclerotic Plaque,303-319, 2020

Ross Ethier, C; Caro, Colin G; Diller, Kenneth R; Guldberg, Robert E; Kamm, Roger D; Platt, Manu O; Yoganathan, Ajit P;  In Memoriam Robert M. Nerem, 1937–2020. Journal of Biomechanical Engineering, 142, 6, 2020

Haase, Kristina; Offeddu, Giovanni S; Gillrie, Mark R; Kamm, Roger D; Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model. Advanced Functional Materials, 200244, 2020

Bai J, Khajavi M, Sui L, Fu H, Tarakkad Krishnaji S, Birsner AE, Bazinet L, Kamm RD, D'Amato RJ. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes. Angiogenesis. 2020 Sep 21. doi: 10.1007/s10456-020-09746-6. PMID: 32955682

SWL Lee, M Campisi, T Osaki, L Possenti, C Mattu, G Adriani, RD Kamm, ... Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature.  Advanced Healthcare Materials 9 (7), 1901486

Campisi M, Sundararaman SK, Shelton SE, Knelson EH, Mahadevan NR, Yoshida R, Tani T, Ivanova E, Cañadas I, Osaki T, Lee SWL, Thai T, Han S, Piel BP, Gilhooley S, Paweletz CP, Chiono V, Kamm RD, Kitajima S, Barbie DA. Tumor-Derived cGAMP Regulates Activation of the Vasculature. Front Immunol. 2020 Sep 4;11:2090. doi: 10.3389/fimmu.2020.02090. eCollection 2020.

Garreta E, Kamm RD, Chuva de Sousa Lopes SM, Lancaster MA, Weiss R, Trepat X, Hyun I, Montserrat. Rethinking organoid technology through bioengineering. Nat Mater. 2020 Nov 16. doi: 10.1038/s41563-020-00804-4.

Douglas SA, Haase K, Kamm RD, Platt MO. Cysteine cathepsins are altered by flow within an engineered in vitro microvascular niche. APL Bioeng. 2020 Nov 4;4(4):046102. doi: 10.1063/5.0023342. eCollection 2020 Dec.

Bai, J., Haase, K., Roberts, J.J., Hoffmann, J., Nguyen, H.T., Wan, Z., Zhang, S., Sarker, B., Friedman, N., Ristić-Lehmann, Č. and Kamm, R.D., 2020. A novel 3D vascular assay for evaluating angiogenesis across porous membranes. Biomaterials, p.120592.

Shelton, S.E., Nguyen, H.T., Barbie, D.A. and Kamm, R.D., 2020. Engineering approaches for studying immune-tumor cell interactions and immunotherapy. iScience, p.101985.

Hajal C, Ibrahim L, Serrano JC, Offeddu GS, Kamm RD. The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform. Biomaterials. 2021 Jan;265:120470. doi: 10.1016/j.biomaterials.2020.120470. Epub 2020 Oct 19. PMID: 33190735

Zhang, S., Wan, Z. and Kamm, R.D., 2021. Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature. Lab on a Chip21(3), pp.473-488.

Kamm, R.D., 2021. Toward improved models of human cancer: Two perspectives. APL Bioeng. 2021 Feb 19;5(1):010402. doi: 10.1063/5.0042324. eCollection 2021 Mar. PMID: 33644625

Offeddu, G.S., Serrano, J.C., Chen, S.W., Shelton, S.E., Shin, Y., Floryan, M. and Kamm, R.D., 2021. Microheart: A microfluidic pump for functional vascular culture in microphysiological systems. Journal of Biomechanics, 2021 Feb 14;119:110330. doi: 10.1016/j.jbiomech.2021.110330. PMID: 33631662

Offeddu, G.S., Hajal, C., Foley, C.R., Wan, Z., Ibrahim, L., Coughlin, M.F. and Kamm, R.D., 2021. The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination. Communications Biology, 4(1), pp.1-10. PMID: 33631662

Bai, J., Khajavi, M., Sui, L., Fu, H., Krishnaji, S.T., Birsner, A.E., Bazinet, L., Kamm, R.D. and D’Amato, R.J., 2021. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes. Angiogenesis24(1), pp.111-127.

Roberts, A.B., Zhang, J., Singh, V.R., Nikolić, M., Moeendarbary, E., Kamm, R.D., So, P.T. and Scarcelli, G., 2021. Tumor cell nuclei soften during transendothelial migration. Journal of Biomechanics121, p.110400.

Hajal, C., Le Roi, B., Kamm, R.D. and Maoz, B.M., 2021. Biology and Models of the Blood–Brain Barrier. Annual Review of Biomedical Engineering23, pp.359-384.

Serrano, J.C., Gupta, S.K., Kamm, R.D. and Guo, M., 2021. In pursuit of designing multicellular engineered living systems: A fluid mechanical perspective. Annual Review of Fluid Mechanics53, pp.411-437.

Hajal, C., Shin, Y., Li, L., Serrano, J.C., Jacks, T. and Kamm, R.D., 2021. The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain. Science Advances7(26), p.eabg8139.

Gilardi, M., Bersini, S., Valtorta, S., Proietto, M., Crippa, M., Boussommier-Calleja, A., Labelle, M., Moresco, R.M., Vanoni, M., Kamm, R.D. and Moretti, M., 2021. The driving role of the Cdk5/Tln1/FAKS732 axis in cancer cell extravasation dissected by human vascularized microfluidic models. Biomaterials, p.120975.

Wan, Z., Zhang, S., Zhong, A.X., Shelton, S.E., Campisi, M., Sundararaman, S.K., Offeddu, G.S., Ko, E., Ibrahim, L., Coughlin, M.F. and Liu, T., 2021. A robust vasculogenic microfluidic model using human immortalized endothelial cells and Thy1 positive fibroblasts. Biomaterials, p.121032.

Vila, O.F., Chavez, M., Ma, S.P., Yeager, K., Zholudeva, L.V., Colón-Mercado, J.M., Qu, Y., Nash, T.R., Lai, C., Feliciano, C.M. and Carter, M., 2021. Bioengineered optogenetic model of human neuromuscular junction. Biomaterials276, p.121033.

Grass, M., McDougal, A.D., Blazeski, A., Kamm, R.D., García-Cardeña, G. and Dewey Jr, C.F., 2022. A computational model of cardiomyocyte metabolism predicts unique reperfusion protocols capable of reducing cell damage during ischemia/reperfusion. Journal of Biological Chemistry, p.101693.

Maurissen, T.L., Pavlou, G., Bichsel, C., Villaseñor, R., Kamm, R.D. and Ragelle, H., 2022. Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature. Journal of Personalized Medicine12(2), p.148.

Kim, M.C., Li, R., Abeyaratne, R., Kamm, R.D. and Asada, H.H., 2022. A computational modeling of invadopodia protrusion into an extracellular matrix fiber network. Scientific Reports12(1), pp.1-19.

Hajal, C., Offeddu, G.S., Shin, Y., Zhang, S., Morozova, O., Hickman, D., Knutson, C.G. and Kamm, R.D., 2022. Engineered human blood–brain barrier microfluidic model for vascular permeability analyses. Nature protocols, pp.1-34.

Patents

  • United States Patent 4,446,747 Kamm May 8, 1984 Method and apparatus for testing lip pressure applied to a smoking article and for calibrating the pressure testing apparatus
  • United States Patent 5,954,745 Gertler and Kamm, September 21, 1999
  • Catheter-filter set having a compliant seal (patent rights to Embolic Protection, Inc., subsequently purchased by Boston Scientific)
  • United States Patent 6,117,087 Kamm,  et al. September 12, 2000 Method and apparatus for noninvasive assessment of a subject's cardiovascular system
  • United States Patent 6,605,053 Kamm,  et al. August 12, 2003 Conduit designs and related methods for optimal flow control
  • PCT/US 20110159522 Application, Kamm et al., Filed April, 2008 Three-dimensional microfluidic platforms and methods of use thereof
  • Provisional patent application, Borenstein et al., October 6, 2009. Improvements to three-dimensional microfluidic platforms and methods of use thereof
  • PCT/US11/54029, Kamm et al., Filed October 19, 2010 Device for High Throughput Investigations of Multi-Cellular Interactions
  • United States Patent Application No. 13/743,223, Ragunath et. al., Filed January 16, 2013 Compositions and Methods for Neovasuclarization