Roger Kamm

Research Interests

• Microfluidics
• Cell mechanics
• Biological systems
• Neurologicasl disease
• Tissue engineering
• Metastatic cancer
• Microvascular models

Online Data

• Google Scholar: (https://scholar.google.com/citations?sortby=pubdate&hl=en&user=NfKZXMUAAAAJ&view_op=list_works)
• ResearchGate: (https://www.researchgate.net/profile/Roger_Kamm)

Honors + Awards

• 2020    Fellow, National Academy of Engineering (NAE)
• 2020    Shu Chien Achievement Award (BMES CMBE), for contributions to the field of cellular and molecular bioengineering
• 2018    The Nerem Medal (ASME) for excellence in education and mentoring
• 2015    The Huiskes Medal (European Biomechanics Society) for lifetime of contributions
• 2011    Honorary Member (American Venous Forum)
• 2010    Fellow, AAAS
• 2010    The Lissner Medal (ASME) for career contributions in bioengineering
• 2010    Elected to the Institute of Medicine of the National Academies
• 2005    Fellow, International Academy of Medical and Biological Engineering
• 2004    Fellow, American Society of Mechanical Engineers
• 2004    Fellow, Biomedical Engineering Society
• 2002    Eschbach Distinguished Visiting Scholar Award, Northwestern University
• 2001    Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching

Related Experience

• 1986-1987 :      Senior Visiting Scientist, University of Cambridge, Department of Applied Mathematics and Theoretical Physics. Visiting Fellow, Clare Hall, University of Cambridge

Memberships

• American Society of Mechanical Engineers
• Biomedical Engineering Society
• America Association for the Advancement of Science
• American Institute of Medical and Biological Engineering
• European Biomechanics Society
• International Academy of Medical and Biological Engineering
• American Venous Forum
• National Academy of Medicine
• National Academy of Engineering

Professional Service

• Editorial Boards: Journal of Multiscale Modeling, Cellular and Molecular Bioengineering, Methods in Cell Science, Cellular and Molecular Bioengineering, Biomedical Engineering Letters, Journal Royal Society Interface
• 2010 - 2020    Director, NSF Center on Emergent Behaviors of Integrated Cellular Systems
• 2014                Chair, World Congress of Biomechanics
• 2011 – 2015    Chair, International Academy of Medical & Biological Engineers
• 2007 – 2010    Director, Global Enterprise for MicroMechanics and Molecular Medicine
• 2004 – 2009    Hypertension and Microcirculation Study Section (regular member)
• 2003 – 2008    BMES Publications Board (Chair, 2004 – 2006), Board of Directors (2005 – 2008)
• 2001                Chair, Summer Bioengineering Conference, Snowbird Utah
• 1998 – 2018    World Council on Biomechanics (Vice Chair, 2002-2006, Chair, 2006-2010)
• 1997 – 2009    US National Committee on Biomechanics (Secretary-treasurer, 2000 – 03, Vice Chair, 2003 – 2006, Chair, 2006-2009)

Teaching

• Molecular, Cellular and Tissue Biomechanics (20.310, 20.410, 2.797, 2.798)
• Fields, Forces and Flows in Biological Systems (20.430, 2.795)

Publications

Recent Publications (in the past 2 years):

Grass, M., McDougal, A.D., Blazeski, A., Kamm, R.D., García-Cardeña, G. and Dewey Jr, C.F., 2022. A computational model of cardiomyocyte metabolism predicts unique reperfusion protocols capable of reducing cell damage during ischemia/reperfusion. Journal of Biological Chemistry, p.101693.

Maurissen, T.L., Pavlou, G., Bichsel, C., Villaseñor, R., Kamm, R.D. and Ragelle, H., 2022. Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature. Journal of Personalized Medicine, 12(2), p.148.

Kim, M.C., Li, R., Abeyaratne, R., Kamm, R.D. and Asada, H.H., 2022. A computational modeling of invadopodia protrusion into an extracellular matrix fiber network. Scientific Reports, 12(1), pp.1-19.

Hajal, C., Offeddu, G.S., Shin, Y., Zhang, S., Morozova, O., Hickman, D., Knutson, C.G. and Kamm, R.D., 2022. Engineered human blood–brain barrier microfluidic model for vascular permeability analyses. Nature protocols, pp.1-34.

Aydin, O., Passaro, A.P., Raman, R., Spellicy, S.E., Weinberg, R.P., Kamm, R.D., Sample, M., Truskey, G.A., Zartman, J., Dar, R.D. and Palacios, S., 2022. Principles for the design of multicellular engineered living systems. APL bioengineering, 6(1), p.010903.

Wan, Z., Zhong, A.X., Zhang, S., Pavlou, G., Coughlin, M.F., Shelton, S.E., Nguyen, H.T., Lorch, J.H., Barbie, D.A. and Kamm, R.D., 2022. A Robust Method for Perfusable Microvascular Network Formation In Vitro. Small Methods, p.2200143.

Kim, H., Kamm, R.D., Vunjak-Novakovic, G. and Wu, J.C., 2022. Progress in multicellular human cardiac organoids for clinical applications. Cell Stem Cell, 29(4), pp.503-514.

Ko, E. and Kamm, R.D., 2022. Neurovascular models for organ-on-a-chips. In vitro models, pp.1-3.

Ibrahim, L.I., Hajal, C., Offeddu, G.S., Gillrie, M.R. and Kamm, R.D., 2022. Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases. Biomaterials, p.121728.

Zhang, Shun, Zhengpeng Wan, Georgios Pavlou, Amy X. Zhong, Liling Xu, and Roger D. Kamm. "Interstitial Flow Promotes the Formation of Functional Microvascular Networks In Vitro through Upregulation of Matrix Metalloproteinase‐2." Advanced Functional Materials 32, no. 43 (2022): 2206767.

Campisi, M., Shelton, S.E., Chen, M., Kamm, R.D., Barbie, D.A. and Knelson, E.H., 2022. Engineered Microphysiological Systems for Testing Effectiveness of Cell-Based Cancer Immunotherapies. Cancers, 14(15), p.3561.

Kim, H., Osaki, T., Kamm, R.D. and Asada, H.H., 2022. Tri‐culture of spatially organizing human skeletal muscle cells, endothelial cells, and fibroblasts enhances contractile force and vascular perfusion of skeletal muscle tissues. FASEB Journal.

Zhang, S., Kan, E.L. and Kamm, R.D., 2022. Integrating functional vasculature into organoid culture: A biomechanical perspective. APL bioengineering, 6(3), p.030401.

Kim, H., Kamm, R.D., Vunjak-Novakovic, G. and Wu, J.C., 2022. Progress in multicellular human cardiac organoids for clinical applications. Cell Stem Cell, 29(4), pp.503-514.

Filippi, Miriam, Oncay Yasa, Roger D Kamm, Ritu Raman, and Robert K. Katzschmann. "Will microfluidics enable functionally integrated biohybrid robots?." Proceedings of the National Academy of Sciences 119, no. 35 (2022): e2200741119.

Haase, K., Piatti, F., Marcano, M., Shin, Y., Visone, R., Redaelli, A., Rasponi, M. and Kamm, R.D., 2022. Physiologic flow-conditioning limits vascular dysfunction in engineered human capillaries. Biomaterials, 280, p.121248.

Straehla, Joelle P., Cynthia Hajal, Hannah C. Safford, Giovanni S. Offeddu, Natalie Boehnke, Tamara G. Dacoba, Jeffrey Wyckoff, Roger D. Kamm, and Paula T. Hammond. "A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles.” Proceedings of the National Academy of Sciences 119, no. 23 (2022): e2118697119.

Ibrahim, L.I., Hajal, C., Offeddu, G.S., Gillrie, M.R. and Kamm, R.D., 2022. Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases. Biomaterials. 2022 Sep;288:121728. doi: 10.1016/j.biomaterials.2022.121728. Epub 2022 Aug 16. PMID: 35995621

Cable J, Arlotta P, Parker KK, Hughes AJ, Goodwin K, Mummery CL, Kamm RD, Engle SJ, Tagle DA, Boj SF, Stanton AE, Morishita Y, Kemp ML, Norfleet DA, May EE, Lu A, Bashir R, Feinberg AW, Hull SM, Gonzalez AL, Blatchley MR, Montserrat Pulido N, Morizane R, McDevitt TC, Mishra D, Mulero-Russe A. Engineering multicellular living systems-A Keystone Symposia report.  Ann N Y Acad Sci. 2022 Sep 30. doi: 10.1111/nyas.14896. 

Kim, H., Osaki, T., Kamm, R.D. and Asada, H., 2022. Multiscale engineered human skeletal muscles with perfusable vasculature and microvascular network recapitulating the fluid compartments. Biofabrication. 2022 Sep 20. doi: 10.1088/1758-5090/ac933d.

Offeddu GS, Serrano JC, Wan Z, Bryniarski MA, Humphreys SC, Chen SW, Dhoolypala H, Conner K, Kamm RD. Microphysiological endothelial models to characterize subcutaneous drug absorption. ALTEX. 2023;40(2):299–313. doi: 10.14573/altex.2207131. Epub 2022 Dec 15. PMID: 36533850.

Badiola-Mateos, M., Osaki, T., Kamm, R.D. and Samitier, J., 2022. In vitro modelling of human proprioceptive sensory neurons in the neuromuscular system. Scientific Reports, 12(1), pp.1-19.

Ciofani, G., Campisi, M., Mattu, C., Kamm, R.D., Chiono, V., Moothedathu Raynold, A., Freitas, J., redolfi riva, E., Micera, S., Pucci, C. and Novio, F., 2022. Roadmap on Nanomedicine for the Central Nervous System. Journal of Physics: Materials.

Spitz, S., Ko, E., Ertl, P. and Kamm, R.D., 2023. How Organ-on-a-Chip Technology Can Assist in Studying the Role of the Glymphatic System in Neurodegenerative Diseases. International Journal of Molecular Sciences, 24(3), p.2171.

Angelidakis E, Chen S, Zhang S, Wan Z, Kamm RD, Shelton SE. Impact of Fibrinogen, Fibrin Thrombi and Thrombin on Cancer Cell Extravasation Using in vitro Microvascular Networks. Adv Healthc Mater. 2023 Apr 29:e2202984. doi: 10.1002/adhm.202202984. Epub ahead of print. PMID: 37119127.

Wan HY, Chen JCH, Xiao Q, Wong CW, Yang B, Cao B, Tuan RS, Nilsson SK, Ho YP, Raghunath M, Kamm RD, Blocki A. Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding. Biomater Res. 2023 Apr 19;27(1):32. doi: 10.1186/s40824-023-00375-w. PMID: 37076899; PMCID: PMC10116810.

Kim DJ, Anandh S, Null JL, Przanowski P, Bhatnagar S, Kumar P, Shelton SE, Grundy EE, Chiappinelli KB, Kamm RD, Barbie DA, Dudley AC. Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors. Nat Commun. 2023 Apr 14;14(1):2122. doi: 10.1038/s41467-023-37807-z. PMID: 37055433; PMCID: PMC10101959.

Rustenhoven J, Pavlou G, Storck SE, Dykstra T, Du S, Wan Z, Quintero D, Scallan JP, Smirnov I, Kamm RD, Kipnis J. Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. J Exp Med. 2023 Jul 3;220(7):e20221929. doi: 10.1084/jem.20221929. Epub 2023 Apr 7. PMID: 37027179; PMCID: PMC10083715.

Javanmardi, Y., Agrawal, A., Malandrino, A., Lasli, S., Chen, M., Shahreza, S., Serwinski, B., Cammoun, L., Li, R., Jorfi, M. and Djordjevic, B., 2023. Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration. Advanced Science, p.2206554.

Serrano, J.C., Gillrie, M.R., Li, R., Ishamuddin, S.H., Moeendarbary, E. and Kamm, R.D., 2023. Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease. Advanced Science, p.2302903.

Maurissen, T.L., Spielmann, A.J., Schellenberg, G., Bickle, M., Vieira, J.R., Lai, S.Y., Pavlou, G., Fauser, S., Westenskow, P.D., Kamm, R.D. and Ragelle, H., 2024. Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip. Nature Communications, 15(1), p.1372.

Cambria, E., Coughlin, M.F., Floryan, M.A., Offeddu, G.S., Shelton, S.E. and Kamm, R.D., 2024. Linking cell mechanical memory and cancer metastasis. Nature Reviews Cancer, pp.1-13.

Patents

• United States Patent 4,446,747 Kamm May 8, 1984 Method and apparatus for testing lip pressure applied to a smoking article and for calibrating the pressure testing apparatus
• United States Patent 5,954,745 Gertler and Kamm, September 21, 1999
• Catheter-filter set having a compliant seal (patent rights to Embolic Protection, Inc., subsequently purchased by Boston Scientific)
• United States Patent 6,117,087 Kamm,  et al. September 12, 2000 Method and apparatus for noninvasive assessment of a subject's cardiovascular system
• United States Patent 6,605,053 Kamm,  et al. August 12, 2003 Conduit designs and related methods for optimal flow control
• PCT/US 20110159522 Application, Kamm et al., Filed April, 2008 Three-dimensional microfluidic platforms and methods of use thereof
• Provisional patent application, Borenstein et al., October 6, 2009. Improvements to three-dimensional microfluidic platforms and methods of use thereof
• PCT/US11/54029, Kamm et al., Filed October 19, 2010 Device for High Throughput Investigations of Multi-Cellular Interactions
• United States Patent Application No. 13/743,223, Ragunath et. al., Filed January 16, 2013 Compositions and Methods for Neovasuclarization