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Roger D. Kamm

Roger D. Kamm

Professor of Biological and Mechanical Engineering
Cecil and Ida Green Distinguished Professor


Room NE47-321
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge MA 02139-4307
Phone: 617-253-5330  
Fax: 617-258-5239  
Email:
Web: http://web.mit.edu/meche/mb/

Curriculum Vitae

Administrative Contact:
Sossy Megerdichian
Room NE 47-322
Phone: 617-253-6236  
Email:

Education:

Ph.D. in Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, May, 1977
S.M. in Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, August 1973
B.S. in Mechanical Engineering, Northwestern University, Evanston, IL, June 1972

 

MIT Service:

2011-present: Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering

2010-2011: Singapore Research Professor of Biological and Mechanical Engineering

2005-2010: Germeshausen Professor of Mechanical and Biological Engineering

 

2005-2008: Associate chair of Mechanical Engineering

1998-present: Professor of Bioengineering, M.I.T.
1988-present: Professor of Mechanical Engineering, M.I.T.
1988-2014: Professor of Health Sciences and Technology, M.I.T. and Harvard University
1981-1988: Associate Professor of Mechanical Engineering, M.I.T.
1978-1981: Assistant Professor of Mechanical Engineering, M.I.T.
1977-1978: Lecturer and Research Associate in the Department of Mech. Engineering, M.I.T.
1977: Instructor, M.I.T.

 

Other Related Experience:

2010-present: Director, NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems

1994-present: Associate Director, Center for Biomedical Engineering, M.I.T.
1992-1994: Co-Director: Program in Biomedical Engineering, M.I.T.
1986-1987: Senior Visiting Scientist, University of Cambridge, Department of Applied Mathematics and Theoretical Physics.
Visiting Fellow, Clare Hall, University of Cambridge.

 

Patents (past 5 years):

PCT/US 20110159522 Application, Kamm et al., Filed April, 2008

   Three-dimensional microfluidic platforms and methods of use thereof

Provisional patent application, Borenstein et al., October 6, 2009.

   Improvements to three-dimensional microfluidic platforms and methods of use thereof

PCT/US11/54029, Kamm et al., Filed October 19, 2010

   Device for High Throughput Investigations of Multi-Cellular Interactions

United States Patent Application No. 13/743,223, Ragunath et. al., Filed January 16, 2013

 

Principal Publications (Last two years):

  1. Rahim NA, Pelet S, Kamm RD, So PT. Methodological considerations for global analysis of cellular FLIM/FRET measurements. J Biomed Opt. 2012 Feb;17(2):026013.
  2. Wong KH, Chan JM, Kamm RD, Tien J. Microfluidic Models of Vascular Functions. Annu Rev Biomed Eng. 2012 Apr 23. [Epub ahead of print]
  3. Farahat WA, Wood LB, Zervantonakis IK, Schor A, Ong S, Neal D, Kamm RD, Asada H. Ensemble Analysis of Angiogenic Growth in Three-Dimensional Microfluidic Cell Cultures, PLoS ONE, 7(5), 2012. PMID: 22662145
  4. Yuchun Liu, Swee-Hin Teoh, Mark SK Chong, Eddy SM Lee, Citra N Mattar, Nau’shil K Randhawa, Zhiyong Zhang, Roger D Kamm, Nicholas M Fisk, Mahesh Choolani, Jerry K Y Chan. Vasculogenic and Osteogenesis-Enhancing Potential of Human Umbilical Cord Blood Endothelial Colony-Forming Cells. Stem Cells (2012) 2012 Jul 3. doi: 10.1002/stem.1164. PMID: 22761003
  5. Choong Kim, Seok Chung, Liu Yuchun, Min-Cheol Kim Jerry K. Y. Chan, H. Harry Asada and Roger D. Kamm In vitro angiogenesis assay for the study of cell encapsulation therapy. Lab Chip, 2012, DOI:10.1039/C2LC40182G PMID: 22722695
  6. Shin Y, Han S, Jeon JS, Yamamoto K, Zervantonakis IK, Sudo R, Kamm RD and Chung S. Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels.  Nature Prot, 7(7):1247-1259, 2012, PMID: 22678430
  7. Vickerman V, Kamm RD. Mechanism of a flow-gated angiogenesis switch: early signaling events at cell-matrix and cell-cell junctions. Integr Biol (Camb). 2012 Jun 7. PMID 22722695
  8. Wood LB, Ge R, Kamm RD, Asada HH. Nascent vessel elongation rate is inversely related to diameter in in vitro angiogenesis, Integr. Biol., 2012, DOI: 10.1039/C2IB20054F
  9. Zervantonakis IK, Hughes-Alford SK, Charest JL, Condeelis JS, Gertler FB, Kamm RD.  Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.  Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13515-20. Epub 2012 Aug 6. PMID: 22869695
  10. Funamoto K, Zervantonakis IK, Liu Y, Ochs CJ, Kim C, Kamm RD.  A Novel Microfluidic Platform for High-Resolution Imaging of a Three-Dimensional Cell Culture under a Controlled Hypoxic Environment, Lab Chip, DOI: 10.1039/c0xx00000x
  11. Tharin S, Kothapali CR, Ozdinler PH, Pasquina L, Chung S, Varner J, DeValance S, Kamm R, Macklis JD A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes. Integr Biol, 4, 1398-1405, 2012, DOI: 10.1039/c2ib20019h
  12. Polacheck WJ, Zervantonakis IK, Kamm RD. Tumor cell migration in complex microenvironments, Cell Mol Life Sci, 2012, DOI 10.1007/s00018-012-1115-1
  13. Kim MC, Kim C, Wood L, Neal D, Kamm RD, Asada HH. Integrating focal adhesion dynamics, cytoskeleton remodeling, and actin motor activity for predicting cell migration on 3D curved surfaces of the extracellular matrix. Integr Biol (Camb). 2012 Sep 18. [Epub ahead of print]
  14. Sakar MS, Neal D, Boudou T, Borochin MA, Li Y, Weiss R, Kamm RD, Chen CS, Asada HH. Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. Lab Chip. 2012 Dec. 7; 12(23): 4976-85. Doi: 10.1039/c2lc40338b.
  15. Borau C, Kim TY, Bidone T, García-Aznar JM, Kamm  RD, Dynamic Mechanisms of Cell Rigidity Sensing: Insights from a Computational Model of Actomyosin Networks, PLoS ONE, PONE-D-12-23235R1
  16. Chan JM, Zervantonakis IK, Rimchala T, Polacheck WJ, Whisler J, Kamm RD. Engineering of In Vitro 3D Capillary Beds by Self-Directed Angiogenic Sprouting. PLoS ONE, 2012;7(12):e50582. doi: 10.1371/journal.pone.0050582. PMID: 23226527
  17. Shin Y, Kim H, Han S, Won J, Lee E-S, Kamm RD, Kim J-H, Chung S. Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion, Adv Healthc Mater. 2013 Jun;2(6):790-4. doi: 10.1002/adhm.201200320. Epub 2012 Nov 26. PMID: 23184641
  18. Han S, Yan JJ, Shin Y, Jeon JJ, Won J, Jeong HE, Kamm RD, Kim YJ, Chung S A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils. Lab Chip. 2012 Oct 21;12(20):3861-5. PMID: 22903230
  19. Kalchman J, Fujioka S, Chung S, Kikkawa Y, Mitaka T, Kamm RD, Tanishita K, Sudo R. A Three-Dimensional Microfluidic Tumor Cell Migration Assay to Screen the Effect of Anti-Migratory Drugs and Interstitial Flow. Microfluid Nanofluid, 2012,  DOI 10.1007/s10404-012-1104-6
  20. Aref AR, Huang RY-J, Yu W, Chua K-N, Sun W, Tu T-Y, Sim W-J, Zervantonakis IK, Thiery JP, Kamm RD. Screening therapeutic EMT blocking agents in a three-dimensional microenvironment. Integr Biol (Camb). 2013 Feb;5(2):381-9. doi: 10.1039/c2ib20209c PMID: 23172153 [PubMed - indexed for MEDLINE]
  21. Rimchala T, Kamm RD, Lauffenburger DA. Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines. Integr Biol (Camb). 2013 Jan 10. [Epub ahead of print]  PMID: 23303249
  22. Jeon JS, Zervantonakis IK, Chung S, Kamm RD, Charest JL. In vitro model of tumor cell extravasation. PLoS One. 2013;8(2):e56910. doi: 10.1371/journal.pone.0056910. Epub 2013 Feb 20. PMID: 23437268
  23. Hammond NA, Kamm RD. Mechanical characterization of self-assembling peptide hydrogels by microindentation. J Biomed Mater Res B Appl Biomater. 2013 Mar 26. doi: 10.1002/jbm.b.32906.  PMID: 23529940
  24. Liu F, Wu D, Kamm RD, Chen K. Analysis of nanoprobe penetration through a lipid bilayer. Biochim Biophys Acta. 2013 Mar 20. doi:pii: S0005-2736(13)00074-6. 10.1016/j.bbamem.2013.03.011. PMID: 23524226
  25. Kim MC, Neal DM, Kamm RD, Asada HH. Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol. 2013 Feb;9(2):e1002926. doi: 10.1371/journal.pcbi.1002926. Epub 2013 Feb 28.
  26. Hammond NA, Kamm RD. Mechanical characterization of self-assembling peptide hydrogels by microindentation. J Biomed Mater Res B Appl Biomater. 2013 Aug;101(6):981-90. doi: 10.1002/jbm.b.32906. Epub 2013 Mar 26. PMID: 23529940
  27. Kothapalli CR, Kamm RD. 3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages. Biomaterials. 2013 Aug;34(25):5995-6007. doi: 10.1016/j.biomaterials.2013.04.042. Epub 2013 May 18. PMID: 23694902
  28. Polacheck WJ, Li R, Uzel SG, Kamm RD. Microfluidic platforms for mechanobiology. Lab Chip. 2013 Jun 21;13(12):2252-67. doi: 10.1039/c3lc41393d. Epub 2013 May 7. PMID: 23649165
  29. Hesse WR, Steiner M, Wohlever ML, Kamm RD, Hwang W, Lang MJ. Modular aspects of kinesin force generation machinery. Biophys J. 2013 May 7;104(9):1969-78. doi: 10.1016/j.bpj.2013.03.051.
  30. Borau C, Kamm RD, García-Aznar JM. A time-dependent phenomenological model for cell mechano-sensing. Biomech Model Mechanobiol. 2013 Jun 20. [Epub ahead of print]
  31. Kamm RD, Bashir R. Creating Living Cellular Machines. Ann Biomed Eng. 2013 Sep 5. [Epub ahead of print] PMID: 24006130
  32. Chen MB, Whisler JA, Jeon JS, Kamm RD. Mechanisms of tumor cell extravasation in an in vitro microvascular network platform. Integr Biol (Camb). 2013 Sep 23; 5(10):1262-71. doi: 10.1039/c3ib40149a. PMID: 23995847
  33. Rahim NAA, Pelet S, Mofrad MRK, So PTC, Kamm RD, Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy, Methods (2013), doi: http://dx.doi.org/10.1016/j.ymeth.2013.10.007
  34. Kim MC, Neal DM, Kamm RD, Asada HH, Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol. 2013;9(2):e1002926. doi: 10.1371/journal.pcbi.1002926. Epub 2013 Feb 28.
  35. Ochs CJ, Kasuya J, Pavesi A and Kamm RD, Oxygen levels in thermoplastic microfluidic devices during cell culture, Lab Chip, 2014, 14 (3), 459 - 462, DOI:10.1039/C3LC51160J
  36. Lim SH, Kim C, Aref AR, Kamm RD, Raghunath M, Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting, Integr Biol (Camb), 2013, DOI: 10.1039/c3ib40082d.
  37. Tu TY, Wang Z, Bai J, Sun W, Peng WK, Huang RY, Thiery JP, Kamm RD Rapid Prototyping of Concave Microwells for the Formation of 3D Multicellular Cancer Aggregates for Drug Screening. Adv Healthcare Mater. 2013 Aug 27. doi: 10.1002/adhm.201300151. PMID: 23983140
  38. Whisler JA, Chen MB, Kamm RD. Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System. Tissue Eng Part C Methods. 2013 Dec 13. [Epub ahead of print] PMID: 24151838
  39. Abdul Rahim NA, Pelet S, Mofrad MRK, So PTC, Kamm RD, Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy, Methods, 30 Oct 2013.
  40. Bersini S, Jeon JS, Dubini G, Arrigoni C, Charest JL, Moretti M, Kamm RD, A mircrofluidid 3D in vitro model for specificity of breast cancer metastasis to bone, Biomaterials, 2013, http://dx.doi.org/10.1016/j.biomaterials.2013.11.050
  41. Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA, Vascular Endothelial Growth Factor and Platelet Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context. Mol Cell Proteomics. 2013 Dec;12(12):3704-18. doi: 10.1074/mcp.M113.030528. Epub 2013 Sep 9. PMID: 24023389
  42. Bersini S, Jeon JS, Moretti M, Kamm RD. In vitro models of the metastatic cascade: from local invasion to extravasation. Drug Discov Today. 2013 Dec 17. pii: S1359-6446(13)00424-8. doi: 10.1016/j.drudis.2013.12.006. [Epub ahead of print] PMID: 24361339
  43. Park YK, Tu TY, Lim SH, Clement IJM, Yang SY, Roger D. Kamm RD, In Vitro Microvessel Growth and Remodeling within a Three-dimensional Microfluidic Environment, Cell Mol Bioeng, 2014 Mar 1;7(1):15-25. DOI: 10.1007/s12195-013-0315-6 PMID: 24660039
  44. Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD. Mechanotransduction of fluid stresses governs 3D rheotaxis, Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2447-52. doi: 10.1073/pnas.1316848111. Epub 2014 Feb 3. PMID: 24550267
  45. Tang D, Kamm RD, Yang C, Zheng J, Canton G, Bach R, Huang X, Hatsukami TS, Zhu J, Ma G, Maehara A, Mintz GS, Yuan C. Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: Data, modeling, validation, uncertainty and predictions. J Biomech. 2014 Jan 14. pii: S0021-9290(14)00041-4. doi: 10.1016/j.jbiomech.2014.01.012. [Epub ahead of print]
  46. Jeon JS, Bersini S, Whisler JA, Chen MB, Dubini G, Charest JL, Moretti M, Kamm RD.  Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems. Integr Biol (Camb). 2014 Mar 27. [Epub ahead of print] PMID: 24676392

Scientific & Professional Societies:

American Institute for Medical and Biological Engineering (Fellow)
American Society of Mechanical Engineering (Fellow)
Biomedical Engineering Society (Fellow)

 

Honors & Awards: (last five years).

Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching (2001)
Southwest Mechanics Lecturer (2002)
Eschbach Distinguished Visiting Scholar Award, Northwestern University (2002)
Fellow, American Society of Mechanical Engineering (2003)
Distinguished Lecturer in Biomechanics, Stanford University, (2004)
Fellow, Biomedical Engineering Society (2004)
Fellow, International Academy of Medical and Biological Engineering (2005)

Skalak Memorial Lecture, UC San Diego, (2007)

Midwest Mechanics Lecturer (2007-8)

Lissner Medal (for lifetime achievement), ASME Bioengineering Division (2010)

Fellow, American Academy for the Advancement of Science (2010)

Elected to the Institute of Medicine (2010)

Honorary Member, American Venous Forum (2011)

 

Institutional and Professional Service (last five years):

Biomedical Engineering Society; Chair, Awards Committee (1989-91)

            Board of Directors (1994-1997) (2003-2007)

            Publications Board, Member (2000-2006)

                                    Chair  (2004-2006)

ASME Journal of Biomechanical Engrg., Associate Editor  (1990-1996)

            NHLBI, NIEHS, NASA, NSF; Review Committees (1988-present)

            Journal of Fluids and Structures, Associate Editor (1993-2005)

            US National Committee on Biomechanics; (1997-present)

                                    Secretary (2000-2003)

                                    Vice chair (2003-2006)

                                    Chair (2006-2009)

            World Council on Biomechanics (1998-present);

                                    Vice chair (2002-2006)

                                    Chair (2006-2010)

            External Review Board, City University of New York, Biomedical Engineering Doctoral Program (1999)

            External Advisory Board, Northwestern University, Dept. of Biomedical Engineering (2000-2006)

            Summer Bioengineering Conference, Conference Chair, 2001

            Biomechanics and Modeling in Mechanobiology, Editorial Board, (2001-present)

            External Review Board, Pennsylvania State University, Dept. of Biomedical Engineering (2003)

            External Review Board, Duke University, Dept. of Biomedical Engineering (2003)

            1st Annual Symposium on Frontiers in Biomechanics, Co-organizer, (2003)

            Mechanics & Chemistry of Biosystems, Editorial Board (2003-present)

            Hypertension & Microcirculation Study Section, NIH (2004-2008)

            Expert Panel, Strategy for the EuroPhysiome (STEP) project (2006-2007)

            External Advisory Board, Simbios Center, Stanford University (2006- 2010)

                                    Chair (2008)

            Co-organizer, Summer Course on Molecular and Cell Biomechanics, MIT (2006)

            Co-organizer, Summit of Experts in Biomechanics, Keystone, CO (2007)

            Advisory Board, Indian Institute of Technology, Kampur, (2007- 2008)

            External Review Committee, UC Berkeley Bioengineering Dept., (2007)

            Scientific Advisory Board, VPH Network of Excellence (2007- 2010)

            Director, Global Enterprise for MicroMechanics and Molecular Medicine (GEM4) (2007-2010)

            Co-organizer, The Cell as a Machine Workshop, Arlington, VA (2007)

ExternalExternal Advisory Committee, Chilean Nanotechnology Initiative (2008)

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